Cytologic Features of Inflammatory Rhabdomyoblastic Tumor Using Conventional and Liquid-Based Cytology Preparations: A Case Report.

Diagn CytopatholAug 25, 2026 (epub)
Case ReportPathology (Anatomic & Clinical)Oncology (Medical)

Yohei Yamaguchi, Toru Odate, Keito Ogino et al.

✦ AI-curated · Sources linked

Case in brief

A man in his 60s with pharyngeal discomfort was diagnosed with tonsillar diffuse large B-cell lymphoma. Staging PET-CT also showed focal uptake in the left tibialis anterior muscle, initially raising concern for lymphoma involvement. Ultrasound-guided biopsy suggested inflammatory rhabdomyoblastic tumor (IRMT), confirmed after resection. Cytology showed atypical cells with enlarged, variably shaped nuclei and abundant cytoplasm amid reactive lymphocytes and histiocytes; the atypical cells expressed desmin and MyoD1. After resection, he received R-CHOP for lymphoma. At follow-up less than 6 months after resection, there was no evidence of IRMT recurrence or metastasis.

What made this case unusual

The report details IRMT cytology across imprint, crush, and liquid-based preparations, showing a biphasic pattern of atypical rhabdomyoblastic cells in a lymphocyte- and histiocyte-rich background. Cross-striations were absent, making immunocytochemical confirmation of rhabdomyoblastic differentiation useful.

Diagnostic / clinical pearl

In a lymphocyte- and histiocyte-rich specimen, atypical cells with rhabdomyoblastic features should prompt consideration of IRMT; desmin and MyoD1 positivity can support that differentiation.

Source

PubMed · PMID 42643025

Published in Diagn Cytopathol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

ShareTelegramLinkedIn

AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

More in Pathology (Anatomic & Clinical)

Clinical ResearchPreventive Medicine / Public Health

2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines.

This systematic review and practice guideline, developed by a multidisciplinary panel using NUTRIGRADE, assessed Mediterranean diet evidence across nine health domains and one economic domain.

Nutr RevNov 12, 2026Read summary
Clinical ResearchOrthopedic Surgery

Prevention of Venous Thromboembolism after Total Hip or Knee Replacement.

This multicenter randomized comparative-effectiveness noninferiority trial compared 30 days of aspirin, warfarin, or rivaroxaban for VTE prophylaxis after elective total hip or knee arthroplasty.

N Engl J MedNov 12, 2026Read summary
Clinical ResearchAnesthesiology

Effect of discontinuing antihypertensives on perioperative hypotension in older patients before non-cardiac surgery: multicentre, randomised, double blind, controlled trial.

This multicentre, randomised, double blind, placebo controlled trial assessed whether withholding ACE inhibitors or ARBs on the morning of surgery reduces perioperative hypotension in older adults undergoing non-cardiac…

BMJNov 11, 2026Read summary

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.