Thyroid-stimulating hormone-secreting pituitary neuroendocrine tumor (TSH-PitNet) diagnosed during pregnancy and treated with a somatostatin analog.
Ikuno Kawabata, Jun Ogawa, Tomoko Ichikawa et al.
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Case in brief
A woman in her mid-20s presented during pregnancy with hyperemesis gravidarum and mild palpitations. Blood tests indicated elevated thyroid hormone levels with non-suppressed TSH, leading to the diagnosis of a TSH-secreting pituitary neuroendocrine tumor (TSH-PitNET) confirmed by MRI. She received monthly lanreotide injections and underwent an emergency cesarean delivery at 40 weeks due to severe headache. A transsphenoidal resection was performed three months postpartum.
Diagnostic / clinical pearl
Clinicians should consider TSH-PitNET in pregnant patients presenting with hyperemesis gravidarum and elevated thyroid hormones, particularly when TSH remains elevated.
Why it matters
This case underscores the importance of monitoring and managing TSH-PitNET during pregnancy, demonstrating that conservative treatment can lead to positive outcomes for both mother and infant.