Kikuchi-Fujimoto Disease - A Case Report in a Middle-aged Adult.

Ann Afr MedAug 14, 2026 (epub)
Case ReportPathology (Anatomic & Clinical)Internal Medicine (General)

Adheesh Phalke, Vijayashree Gokhale, Nallani Chakravarthi Sai Sirisha et al.

✦ AI-curated · Sources linked

Case in brief

A 46-year-old woman presented with fever and left posterior cervical lymphadenopathy of 2 weeks’ duration. Tuberculosis testing, including GeneXpert, Mantoux testing, and culture, was negative. Imaging showed multiple necrotic cervical nodes with bilateral involvement. Excisional biopsy demonstrated patchy necrosis with karyorrhectic debris, histiocytes and immunoblasts, and no neutrophilic infiltration, supporting Kikuchi-Fujimoto disease (KFD). She received symptomatic treatment, and her symptoms resolved completely at follow-up.

What made this case unusual

KFD occurred in a middle-aged adult and produced multiple bilateral necrotic cervical nodes, findings that can raise concern for tuberculosis or malignancy.

Diagnostic / clinical pearl

When cervical lymphadenopathy and necrotic nodes persist despite negative tuberculosis testing, KFD should remain in the differential; excisional lymph node biopsy can establish the diagnosis.

Source

PubMed · PMID 42593271

Published in Ann Afr Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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