The Use of Oral Nicotine Pouches in Adolescents: Systematic Review and Meta-Analysis.
Sayda Mohamed Elhag Sirelkhatim, Mustafa Abdelhamied Mohamed Mustafa Abugesiesa, Jadallah Osman Mohammedzein Ali et al.
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In 30 seconds
This systematic review and meta-analysis examined adolescent oral nicotine pouch use, including prevalence, user characteristics, associated factors, and co-use with other substances. A search through September 2025 identified 14 eligible studies. Descriptive synthesis and random-effects meta-analyses found that ever use was more prevalent than current use. Use was more common among males, older adolescents, and those identifying as Hispanic, and was strongly associated with use of other tobacco products and substances. The abstract does not report pooled prevalence estimates or other numerical effect sizes.
Key findings
- Across the included studies, ever use of oral nicotine pouches was more prevalent than current use.
- Use was associated with male gender, older age, and Hispanic ethnicity.
- Oral nicotine pouch use was strongly associated with co-use of other tobacco products and substances.
Why it matters
The findings indicate that adolescent pouch use occurs alongside use of other substances and varies across demographic groups. Recognising these patterns can inform surveillance and help identify areas for prevention and further research, while the review’s evidence does not establish that pouch use causes other substance use or health outcomes.
What to keep in mind
The review’s conclusions depend on the 14 eligible studies; the abstract provides no pooled prevalence estimates or details on study populations and follow-up.