Successful Treatment of Highly Resistant Trichomoniasis with Tinidazole and Paromomycin Regimen after Boric Acid Failure.
Karley Dutra, Paul Nyirjesy
✦ AI-curated · Sources linked
Case in brief
Two patients with Trichomonas vaginalis infection had persistent disease despite high-dose tinidazole and boric acid. Both were subsequently treated successfully with a regimen combining tinidazole and paromomycin. The report describes these treatment failures and outcomes in the context of increasing metronidazole and tinidazole resistance; the abstract does not provide further clinical findings or treatment details.
What made this case unusual
Both patients had failed high-dose tinidazole and boric acid before responding to the tinidazole–paromomycin regimen.
Diagnostic / clinical pearl
For persistent T. vaginalis infection after high-dose tinidazole and boric acid, this report describes successful treatment with tinidazole plus paromomycin.
Why it matters
Paromomycin cream with high-dose tinidazole may be limited by vulvovaginal ulceration, an adverse effect relevant to considering this regimen.