Giant Centrifugal Miliaria Profunda.

J Cutan PatholJul 25, 2026 (epub)
Case ReportDermatologyPathology (Anatomic & Clinical)PediatricsMedical Genetics

Ruth Alperovich, Anthony J Mancini, Daniela Montanari et al.

✦ AI-curated · Sources linked

Case in brief

The report describes two infants with giant centrifugal miliaria profunda (GCMP), a form of miliaria profunda characterized by centrifugal enlargement of large annular plaques. Histology showed epidermal hyperkeratosis and acanthosis, obstructed and distended sweat ducts, and dilated dermal ducts with squamous metaplasia. Inflammation around ducts and eccrine structures varied and included neutrophils; granulomatous inflammation was often present. One case was associated with a germline MAP2K1 RASopathy. The abstract does not describe treatment or clinical resolution.

What made this case unusual

GCMP combines a distinctive centrifugal expansion of large annular plaques with characteristic sweat-duct changes; one reported case also had a germline MAP2K1 RASopathy.

Diagnostic / clinical pearl

In an infant with expanding annular plaques, consider GCMP and correlate the clinical pattern with obstructed, dilated sweat ducts and periductal inflammation on histology.

Source

PubMed · PMID 42502171

Published in J Cutan Pathol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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