Lichenoid and Granulomatous Stomatitis: Three Additional Cases and Detailed Immunohistochemical Analysis.
Mariana Paravani Palaçon, Karina Kendelhy Santos, Karina Helen Martins et al.
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Case in brief
The report describes three cases of lichenoid and granulomatous stomatitis (LGS), assessed histologically and by immunohistochemistry alongside comparison groups with oral lichen planus, oral lichenoid lesions, and oral leukoplakia with lichenoid infiltrate. All LGS specimens had lymphohistiocytic inflammation, microgranulomas, and perivascular and perineural lymphohistiocytic aggregates. Compared with the other lesions, LGS showed greater numbers of macrophages, CD3+ and CD8+ T cells, FOXP3+ regulatory T cells, and submucosal dendritic cells; Langerhans cells were similarly observed and CD20+ B cells were scarce.
What made this case unusual
The combination of microgranulomas with perivascular and perineural lymphohistiocytic aggregates, together with a distinctive macrophage, T-cell, and submucosal dendritic-cell profile, characterized these LGS cases relative to the comparison lesions.
Diagnostic / clinical pearl
In a lichenoid oral lesion, microgranulomas and perivascular or perineural lymphohistiocytic aggregates can support consideration of LGS; the reported immunohistochemical profile may help distinguish it from other lichenoid lesions.