GLP-1 receptor agonists in multiple sclerosis: a systematic review of preclinical and clinical evidence.

Mult Scler Relat DisordJul 10, 2026 (epub)
Clinical ResearchNeurology

Mobeen Sajjad, Ahsan Sajjad, Rida Amer et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review evaluated the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in multiple sclerosis (MS) through 15 studies, including preclinical and human data. The review found that GLP-1RAs reduced clinical severity in animal models and were associated with BMI reduction in humans, but did not affect EDSS or relapse rates. Most preclinical studies had a high risk of bias.

Key findings

  • GLP-1RAs reduced clinical severity in EAE models through various neuroprotective mechanisms.
  • In humans, GLP-1RA use was associated with BMI reduction and vitamin D augmentation.
  • No change in EDSS or relapse rate was observed in human studies.
  • Pharmacovigilance indicated inverse reporting odds ratios for semaglutide, dulaglutide, and liraglutide.

Why it matters

Understanding the potential benefits and safety of GLP-1RAs in MS could inform future treatment strategies, especially given their metabolic benefits without neurological harm. This evidence may guide clinicians in considering GLP-1RAs for MS patients.

What to keep in mind

Most preclinical studies were assessed as having a high risk of bias, and human studies were of moderate to high quality.

Source

PubMed · PMID 42470876

Published in Mult Scler Relat Disord. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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