Double-Negative Neuromyelitis Optica Spectrum Disorder: A Systematic Review and Meta-Analysis.

Neurol Neuroimmunol NeuroinflammJul 17, 2026 (epub)
Clinical ResearchNeurologyOpen access

Antonio Malvaso, Francesca Bovis, Giacomo Greco et al.

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In 30 seconds

This systematic review and meta-analysis examined double-negative neuromyelitis optica spectrum disorder (DN-NMOSD) in 671 patients, comparing it to AQP4-NMOSD and MOGAD. The study found that 73.6% of DN-NMOSD patients relapsed, with a mean annualized relapse rate of 1.08. Maintenance immunosuppression significantly reduced relapse rates (pooled rate ratio 0.19).

Key findings

  • 73.6% of patients with DN-NMOSD experienced relapses.
  • Mean annualized relapse rate was 1.08 in DN-NMOSD compared to 0.84 in AQP4-NMOSD.
  • Maintenance immunosuppression led to a significant reduction in relapse rate (pooled rate ratio 0.19).
  • No significant change in disability was observed in DN-NMOSD post-treatment.

Why it matters

Understanding the clinical spectrum and treatment response in DN-NMOSD is crucial for improving management strategies. The high relapse rate highlights the need for effective early intervention to prevent disability.

Source

PubMed · PMID 42468026Free full text on PubMed Central

Published in Neurol Neuroimmunol Neuroinflamm. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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