Serum angiogenesis-hypoxia biomarkers in relapsing-remitting multiple sclerosis.

Mult Scler Relat DisordJun 29, 2026 (epub)
Clinical ResearchNeurology

Heather Y F Yong, Nicholas J Batty, Serena Phillips et al.

✦ AI-curated · Sources linked

In 30 seconds

This randomized controlled trial investigated serum angiogenesis and hypoxia biomarkers in 122 participants with relapsing-remitting multiple sclerosis (RRMS) compared to 78 healthy controls. The study found that hypoxic markers were increased in RRMS, while angiogenic markers remained unchanged, suggesting a relatively preserved hypoxia-angiogenic axis in RRMS compared to progressive MS.

Key findings

  • Increased levels of hypoxia inducible factor-1-a, heme oxygenase-1, and heat shock protein-90 were found in RRMS serum.
  • Brain derived neurotrophic factor was reduced in RRMS participants.
  • Lysyl oxidase levels correlated negatively with lesion texture and brain volume.

Why it matters

Understanding the differences in biomarker profiles between relapsing-remitting and progressive multiple sclerosis can inform treatment strategies and enhance the understanding of disease mechanisms, potentially guiding future therapeutic developments.

Source

PubMed · PMID 42431138

Published in Mult Scler Relat Disord. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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