Dupilumab-Associated Erythema Multiforme-Like Eruption With Lichenoid Histology in a Paediatric Patient: A Case Report.

Australas J DermatolJul 7, 2026 (epub)
Case ReportDermatologyPediatricsPathology (Anatomic & Clinical)

Paul Sun Woo Kim, Jacqueline Tu, Kelvin Truong et al.

✦ AI-curated · Sources linked

Case in brief

A 5-year-old boy with eczema developed erythematous targetoid papules and plaques on his upper and lower limbs while receiving dupilumab. Skin biopsy showed a lichenoid interface reaction, supporting an erythema multiforme-like eruption with lichenoid histology. Dupilumab was discontinued, and the eruption was treated with topical corticosteroids. The lesions resolved, leaving mild post-inflammatory hyperpigmentation.

What made this case unusual

The eruption had an erythema multiforme-like clinical appearance but lichenoid interface histology in a paediatric patient receiving dupilumab.

Diagnostic / clinical pearl

Targetoid lesions during dupilumab therapy may have lichenoid histology; biopsy can help characterize an erythema multiforme-like drug-associated eruption.

Source

PubMed · PMID 42415502

Published in Australas J Dermatol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

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