Effects of physical exercise on neurofilament light chain in multiple sclerosis and other neurological disorders: A systematic review.

Mult Scler Relat DisordJun 29, 2026 (epub)
Clinical ResearchNeurology

Alberto De León-Muñoz, Jacobo Á Rubio-Arias, Vicente Ávila-Gandía et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review evaluated the effects of physical exercise on neurofilament light chain (NfL) levels in individuals with multiple sclerosis (MS) and other neurological disorders. The analysis included 15 studies with 765 patients, primarily focusing on MS. Significant reductions in NfL were observed following resistance training, Pilates, and high-intensity interval training (HIIT) in MS patients, while other exercise types showed no significant effects.

Key findings

  • In MS, resistance training, Pilates, and HIIT significantly reduced NfL concentrations.
  • Prolonged moderate-to-high intensity aerobic exercise had no significant effects on NfL in MS or other disorders.
  • Resistance-based programs also led to reductions in GFAP and tau protein levels.

Why it matters

Understanding the impact of exercise on biomarkers like NfL can inform treatment strategies for neurodegenerative diseases. This knowledge may help clinicians recommend specific exercise modalities to potentially enhance neuroprotection in patients with MS.

Source

PubMed · PMID 42413317

Published in Mult Scler Relat Disord. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

ShareTelegramLinkedIn

AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

More in Neurology

Clinical ResearchPreventive Medicine / Public Health

2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines.

This systematic review and practice guideline, developed by a multidisciplinary panel using NUTRIGRADE, assessed Mediterranean diet evidence across nine health domains and one economic domain.

Nutr RevNov 12, 2026Read summary
Clinical ResearchOrthopedic Surgery

Prevention of Venous Thromboembolism after Total Hip or Knee Replacement.

This multicenter randomized comparative-effectiveness noninferiority trial compared 30 days of aspirin, warfarin, or rivaroxaban for VTE prophylaxis after elective total hip or knee arthroplasty.

N Engl J MedNov 12, 2026Read summary
Clinical ResearchAnesthesiology

Effect of discontinuing antihypertensives on perioperative hypotension in older patients before non-cardiac surgery: multicentre, randomised, double blind, controlled trial.

This multicentre, randomised, double blind, placebo controlled trial assessed whether withholding ACE inhibitors or ARBs on the morning of surgery reduces perioperative hypotension in older adults undergoing non-cardiac…

BMJNov 11, 2026Read summary

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.