Crigler-Najjar Syndrome (Type 1) - A Case Report and Review of Literature.

Ann Afr MedJul 1, 2026 (epub)
Case ReportPediatricsMedical GeneticsNeurology

Elham Nazari Fard, Ali Al Yasari, Asmaa Sharafeldin et al.

✦ AI-curated · Sources linked

Case in brief

A 7-year-old girl with Crigler–Najjar syndrome type I and kernicterus presented with fever and breakthrough seizures during an upper respiratory infection. She had severe neurodevelopmental impairment, including spastic quadriplegic cerebral palsy, epilepsy, global developmental delay, and failure to thrive. The report attributes her neurological sequelae to untreated neonatal hyperbilirubinemia and emphasizes early diagnosis and aggressive management.

What made this case unusual

The report describes a child with established kernicterus and profound, irreversible neurological impairment presenting with breakthrough seizures during an upper respiratory infection.

Diagnostic / clinical pearl

Crigler–Najjar syndrome type I causes severe unconjugated hyperbilirubinemia; untreated neonatal hyperbilirubinemia can result in irreversible neurological sequelae.

Source

PubMed · PMID 42389952

Published in Ann Afr Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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