Clinical features, imaging findings, and treatment outcomes of optic neuritis associated with anti-CRMP5 antibodies: a systematic review.

J NeuroimmunolJun 27, 2026 (epub)
Clinical ResearchNeurologyOncology (Medical)

Rafael Martins Themoteo, Yang Han Yu, Joana Laura Aihara Barbosa et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review analyzed 32 patients with optic neuritis associated with anti-CRMP5 antibodies. The study found that 87.1% had bilateral optic neuritis, with 64% experiencing visual acuity worse than 20/200. A significant 90.6% had an associated malignancy, primarily small-cell lung carcinoma. Overall mortality was 32.1% at a median follow-up of 9.5 months.

Key findings

  • 87.1% of patients had clinically symptomatic bilateral optic neuritis.
  • Overall mortality was 32.1% at a median follow-up of 9.5 months.
  • 90.6% of cases had an associated malignancy, mostly small-cell lung carcinoma.
  • Absence of tumor response to treatment was linked to 88.9% mortality.

Why it matters

Understanding the clinical features and outcomes of optic neuritis related to anti-CRMP5 antibodies is crucial for timely diagnosis and management, especially given the high association with malignancies and significant mortality rates.

Source

PubMed · PMID 42372569

Published in J Neuroimmunol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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