A Randomized Controlled Trial of an iCBT Program to Reduce Infertility-Related Stress: A Novel Digital Approach.
Sigurbirna Haflidadottir, Fjola Dogg Helgadottir, Magnus Blondahl Sighvatsson
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In 30 seconds
This randomized controlled trial compared a fully automated online cognitive behavioral therapy program, Overcome Fertility Stress, with a waitlist control in 63 Icelandic women experiencing infertility-related stress. Intention-to-treat analyses found a significant within-group reduction in infertility-related stress among intervention participants (mean reduction score = 22.85, p < 0.05), while the control group had no significant change (p > 0.05). No significant effects were observed for depression, anxiety, general stress, or worry. The authors describe the evidence as preliminary and advise caution because the sample was underpowered and adherence was low.
Key findings
- Intervention participants had a mean infertility-related stress reduction score of 22.85 (p < 0.05); the waitlist group showed no significant change (p > 0.05).
- No significant effects were found on secondary measures of depression, anxiety, stress, or worry.
- The authors report low adherence and an underpowered sample, limiting confidence in the treatment benefit.
Why it matters
Infertility-related distress can be difficult to address when psychological support is inaccessible. This trial offers preliminary evidence that an automated digital CBT program may reduce distress specifically related to infertility, while not demonstrating broader improvements in emotional symptoms. The findings highlight both the potential reach of low-intensity digital support and the need for stronger evidence on its effectiveness.
What to keep in mind
The sample was underpowered, adherence was low, and the abstract notes that controlled between-group effects and confidence intervals should be prioritized when interpreting benefit.