Hypersexuality across neurological disorders: A systematic review of aetiologies, clinical manifestations, assessment methods, and management strategies.

Neurosci Biobehav RevJun 22, 2026 (epub)
Clinical ResearchNeurology

Alexa Schincariol, Rachele Pezzetta, Maria Devita et al.

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In 30 seconds

This systematic review analyzed 394 studies involving 46,516 participants to explore hypersexuality (HY) in neurological disorders. The majority of cases (≈61%) were iatrogenic, primarily linked to dopaminergic therapy in Parkinson's disease. The review highlights the need for improved assessment and management strategies for this under-recognized behavioral complication.

Key findings

  • Approximately 61% of hypersexuality cases were iatrogenic, mainly due to dopaminergic therapy in Parkinson's disease.
  • About 25% of cases were acquired from focal lesions, traumatic brain injury, or neurodegenerative syndromes.
  • Nearly half of the studies relied solely on unstructured notes for assessment.
  • Less than 10% of studies formally consulted informants for assessment.

Why it matters

Hypersexuality is a significant behavioral complication in neurological disorders that can impact patient quality of life and caregiver burden. Understanding its aetiology and management is crucial for effective clinical practice.

Source

PubMed · PMID 42330690

Published in Neurosci Biobehav Rev. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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