Quality of life outcomes in neuropathic orofacial pain: an umbrella review of therapeutic interventions.

Pain ManagJun 13, 2026 (epub)
Clinical ResearchNeurology

Javier Basualdo Allende, Gilbert Jorquera, Vanessa Campos-Bijit et al.

✦ AI-curated · Sources linked

In 30 seconds

This umbrella review synthesized evidence from seven systematic reviews on therapeutic interventions for neuropathic orofacial pain and their impact on quality-of-life outcomes. Repetitive transcranial magnetic stimulation was associated with improved patient-reported outcomes (MD -9.23; 95% CI -11.91 to -6.54), while other treatments showed varying effects on pain and functional recovery. The study highlights the need for more robust evidence.

Key findings

  • Repetitive transcranial magnetic stimulation improved selected patient-reported domains (MD -9.23; 95% CI -11.91 to -6.54).
  • Microvascular decompression provided sustained pain relief and inferred benefits in satisfaction and functional recovery.
  • Pulsed radiofrequency improved short-term pain and sleep outcomes.
  • Botulinum toxin type A reduced pain but did not improve broader quality-of-life domains.

Why it matters

Understanding the impact of various treatments on quality of life in patients with neuropathic orofacial pain is crucial for clinicians to make informed decisions about management strategies that enhance patient well-being.

Source

PubMed · PMID 42287136

Published in Pain Manag. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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