Bipolar disorder and the risk of developing dementia - a systematic review and meta-analysis.

Curr Opin PsychiatryMay 20, 2026 (epub)
Clinical ResearchPsychiatry

Lars Vedel Kessing, Klaus Munkholm

✦ AI-curated · Sources linked

In 30 seconds

This systematic review and meta-analysis examined the risk of dementia in patients with bipolar disorder, analyzing data from 22 studies involving 185,306 patients with bipolar disorder and 10,702,744 without. The findings indicated a significantly increased risk of dementia in bipolar patients, with an odds ratio of 3.13 (95% CI: 2.40-4.09).

Key findings

  • Patients with bipolar disorder have an odds ratio of 3.13 for developing dementia compared to those without.
  • In a secondary analysis, the odds ratio was 2.60 when excluding studies with overlapping populations.
  • The analysis included 21 studies contributing to the meta-analysis.
  • Substantial heterogeneity was noted among the studies included.

Why it matters

Understanding the increased risk of dementia in patients with bipolar disorder is crucial for clinicians, as it may influence monitoring and management strategies for this population.

What to keep in mind

The evidence was uncertain due to substantial and unexplained between-study heterogeneity, methodological limitations, and risk of bias.

Source

PubMed · PMID 42233646

Published in Curr Opin Psychiatry. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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