Effect of Sleep Duration Manipulation on Brain-Derived Neurotrophic Factor in Adolescents at Risk for Type 2 Diabetes: A Randomized Crossover Study.

J Sleep ResMay 26, 2026 (epub)
Clinical ResearchEndocrinologyPediatrics

Caroline Dutil, Irina Podinic, Jeremy J Walsh et al.

✦ AI-curated · Sources linked

In 30 seconds

This randomized crossover study investigated the impact of sleep duration manipulation on serum brain-derived neurotrophic factor (BDNF) levels in adolescents at risk for type 2 diabetes. The study involved 36 participants who increased and decreased their sleep duration by 1.5 hours for one week each. Increasing sleep duration led to a significant decrease in serum BDNF levels by approximately 14% compared to habitual and decreased sleep conditions.

Key findings

  • Increasing sleep duration resulted in a significant decrease in serum BDNF levels by ~14%.
  • Participants successfully increased sleep duration by +1:02 h/night and decreased it by -1:19 h/night.
  • No significant differences in BDNF levels were observed between habitual and decreased sleep weeks.

Why it matters

Understanding the relationship between sleep duration and BDNF levels in adolescents at risk for type 2 diabetes is crucial, as it may inform strategies to improve metabolic health and manage obesity-related risks in this population.

Source

PubMed · PMID 42192565

Published in J Sleep Res. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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