Constant-routine protocol reveals an endogenous circadian rhythm in diet-induced thermogenesis with a peak in the biological morning.

MetabolismMay 25, 2026 (epub)
Clinical ResearchEndocrinologyGastroenterologyOpen access

Nina Vujović, Han-Chow E Koh, Su Wei Heng et al.

✦ AI-curated · Sources linked

In 30 seconds

This randomized controlled trial investigated the influence of the endogenous circadian system on diet-induced thermogenesis (DIT) in 16 healthy adults with overweight or obesity. The study found a significant circadian rhythm in DIT, peaking in the biological morning with a peak-to-trough amplitude of 44% (∼10 kcal/4 h), suggesting that meal timing may impact body mass through thermogenic responses.

Key findings

  • The peak-to-trough amplitude of DIT was 44% (∼10 kcal/4 h), peaking in the biological morning.
  • Circadian rhythm in DIT remained significant after adjusting for fasting energy expenditure, with a reduced amplitude of ∼29% (∼7 kcal/4 h).
  • The endogenous circadian rhythm in DIT was unaffected by prior early versus late eating schedules.

Why it matters

Understanding the circadian influences on diet-induced thermogenesis can help elucidate mechanisms linking meal timing to body weight regulation, potentially guiding dietary recommendations for weight management.

Source

PubMed · PMID 42190872Free full text on PubMed Central

Published in Metabolism. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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