Comparative diagnostic accuracy of panic provocation tests: A meta-analysis.

J Psychiatr ResMay 20, 2026 (epub)
Clinical ResearchPsychiatry

Umit Tural, Sara Rose Shannon, Dan V Iosifescu

✦ AI-curated · Sources linked

In 30 seconds

This meta-analysis evaluated the diagnostic accuracy of various panic provocation tests in a population of 5693 participants across 123 studies. Sodium lactate infusion demonstrated the highest pooled diagnostic odds ratio (DOR) of 24.77, indicating superior diagnostic discrimination for panic disorder compared to healthy controls. The study utilized random-effects meta-analyses with Hartung-Knapp adjustment.

Key findings

  • Sodium lactate infusion had the highest pooled DOR of 24.77 (95% CI 19.03-32.25).
  • Isoproterenol showed a DOR of 18.85 (95% CI 12.39-28.66).
  • Cholecystokinin tetrapeptide (CCK-4) had a DOR of 15.03 (95% CI 7.83-28.84).
  • Breath holding, fenfluramine, and flumazenil did not show significant discriminative ability.

Why it matters

Understanding the diagnostic accuracy of panic provocation tests is crucial for clinicians in accurately diagnosing panic disorder. This meta-analysis highlights the effectiveness of specific tests, particularly sodium lactate infusion, which may enhance diagnostic precision in clinical practice.

Source

PubMed · PMID 42190597

Published in J Psychiatr Res. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

ShareTelegramLinkedIn

AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

More in Psychiatry

Clinical ResearchPreventive Medicine / Public Health

2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines.

This systematic review and practice guideline, developed by a multidisciplinary panel using NUTRIGRADE, assessed Mediterranean diet evidence across nine health domains and one economic domain.

Nutr RevNov 12, 2026Read summary
Clinical ResearchOrthopedic Surgery

Prevention of Venous Thromboembolism after Total Hip or Knee Replacement.

This multicenter randomized comparative-effectiveness noninferiority trial compared 30 days of aspirin, warfarin, or rivaroxaban for VTE prophylaxis after elective total hip or knee arthroplasty.

N Engl J MedNov 12, 2026Read summary
Clinical ResearchAnesthesiology

Effect of discontinuing antihypertensives on perioperative hypotension in older patients before non-cardiac surgery: multicentre, randomised, double blind, controlled trial.

This multicentre, randomised, double blind, placebo controlled trial assessed whether withholding ACE inhibitors or ARBs on the morning of surgery reduces perioperative hypotension in older adults undergoing non-cardiac…

BMJNov 11, 2026Read summary

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.