Acute myocardial mechanical responses to colloid and crystalloid volume loading: A randomized double-blind crossover study.

Br J Clin PharmacolMay 25, 2026 (epub)
Clinical ResearchCardiologyOpen access

Nidhal Bouchahda, Fabian Scheipl, Haithem Hbid et al.

✦ AI-curated · Sources linked

In 30 seconds

This randomized double-blind crossover trial investigated myocardial mechanical responses to colloid (Gelafundin 4%) versus crystalloid (0.9% sodium chloride) volume loading in 20 healthy volunteers. The study found that left ventricular global longitudinal strain (GLS) differed significantly between the two fluids, with a maximum difference of -1% favoring colloids, indicating distinct myocardial responses to volume resuscitation.

Key findings

  • Left ventricular global longitudinal strain (GLS) differed significantly between fluids, with a maximum difference of -1% favoring colloids.
  • Right ventricular strain showed significant differences primarily during diastole, with a maximum difference of +2%.
  • Left ventricular torsion increased significantly with colloid, showing a maximum difference of +3%.
  • Left atrial strain exhibited the largest differences at both infusion volumes, with a maximum difference of +6%.

Why it matters

Understanding the differential myocardial responses to colloid and crystalloid resuscitation can inform clinical decisions regarding fluid management in patients requiring volume resuscitation, potentially impacting outcomes in critical care settings.

Source

PubMed · PMID 42185240Free full text on PubMed Central

Published in Br J Clin Pharmacol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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