Pacing-Induced Cardiomyopathy in Leadless and Transvenous Pacemakers: A Meta-Analysis and Meta-Regression.

Pacing Clin ElectrophysiolMay 22, 2026 (epub)
Clinical ResearchCardiologyOpen access

Frengki Prabowo Saputro Wijayanto, Artha Maressa Theodora Simanjuntak, Christopher Daniel Tristan et al.

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In 30 seconds

This meta-analysis evaluated the prevalence of pacing-induced cardiomyopathy (PICM) in 3224 patients with leadless pacemakers compared to transvenous systems. The pooled prevalence of PICM following leadless pacing was 13%. The risk of PICM was similar between leadless and transvenous pacing (RR 1.00), while leadless pacing showed a lower rate of cardiac resynchronization therapy upgrade (RR 0.56).

Key findings

  • Pooled prevalence of PICM following leadless pacing was 13% (95%CI: 4%-23%).
  • Risk of PICM was similar between leadless and transvenous pacing (RR 1.00; 95%CI: 0.77-1.29).
  • Leadless pacing was associated with a lower rate of CRT upgrade (RR 0.56; 95%CI: 0.48-0.66).
  • Baseline heart failure was a significant predictor of PICM (p < 0.0001).

Why it matters

Understanding the risk of pacing-induced cardiomyopathy is crucial for clinicians when selecting pacing systems. This study suggests that leadless pacemakers may not increase PICM risk compared to traditional systems, which could influence device choice.

Source

PubMed · PMID 42171073Free full text on PubMed Central

Published in Pacing Clin Electrophysiol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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