Understanding specificity in immune-brain pathways: A systematic review of differential associations between individual cytokines and brain structure and function measured through magnetic resonance imaging in humans.

Brain Behav ImmunMay 20, 2026 (epub)
Clinical ResearchPsychiatry

Andrea L Cordero, Madeleine R Frazier, Geneva M Jost et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review evaluates the associations between individual cytokines and brain structure and function in humans, focusing on studies involving depressed and healthy participants under 65. The review finds that most studies report unique associations between specific cytokines and brain outcomes, suggesting distinct neuromodulatory roles. Notably, interleukin-6 is associated with the default mode network, while tumor necrosis factor-alpha relates to the salience network.

Key findings

  • The majority of studies reported unique associations between individual cytokines and brain outcomes.
  • Interleukin-6 levels are preliminarily associated with the default mode network.
  • Tumor necrosis factor-alpha shows preliminary associations with the salience network.

Why it matters

Understanding the specific associations between cytokines and brain function can enhance insights into the biological underpinnings of psychiatric disorders, potentially guiding future therapeutic strategies.

Source

PubMed · PMID 42167549

Published in Brain Behav Immun. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

ShareTelegramLinkedIn

AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

More in Psychiatry

Clinical ResearchPreventive Medicine / Public Health

2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines.

This systematic review and practice guideline, developed by a multidisciplinary panel using NUTRIGRADE, assessed Mediterranean diet evidence across nine health domains and one economic domain.

Nutr RevNov 12, 2026Read summary
Clinical ResearchOrthopedic Surgery

Prevention of Venous Thromboembolism after Total Hip or Knee Replacement.

This multicenter randomized comparative-effectiveness noninferiority trial compared 30 days of aspirin, warfarin, or rivaroxaban for VTE prophylaxis after elective total hip or knee arthroplasty.

N Engl J MedNov 12, 2026Read summary
Clinical ResearchAnesthesiology

Effect of discontinuing antihypertensives on perioperative hypotension in older patients before non-cardiac surgery: multicentre, randomised, double blind, controlled trial.

This multicentre, randomised, double blind, placebo controlled trial assessed whether withholding ACE inhibitors or ARBs on the morning of surgery reduces perioperative hypotension in older adults undergoing non-cardiac…

BMJNov 11, 2026Read summary

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.