Cost-effectiveness of catheter ablation in end-stage heart failure with atrial fibrillation: Insights from CASTLE-HTx.

Heart RhythmMay 19, 2026 (epub)
Clinical ResearchCardiologyOncology (Medical)

Priyanka Boettger, Maximilian Moersdorf, Philipp Sommer et al.

✦ AI-curated · Sources linked

In 30 seconds

The CASTLE-HTx trial evaluated the cost-effectiveness of catheter ablation combined with guideline-directed medical therapy (GDMT) versus medical therapy alone in 194 patients with end-stage heart failure and atrial fibrillation. The study found that the combination therapy resulted in a mean survival gain of approximately 1.7 life-years per patient at an incremental cost of about €12,000, yielding an incremental cost-effectiveness ratio of approximately €7300 per life-year gained.

Key findings

  • The combination of catheter ablation and GDMT resulted in a mean survival gain of ∼1.7 life-years per patient.
  • The incremental cost-effectiveness ratio was approximately €7300 per life-year gained.
  • At 36 months, the combination therapy provided a gain of 0.34 life-years.
  • Both lifetime and 36-month incremental cost-effectiveness ratios were below €50,000 per QALY.

Why it matters

Understanding the cost-effectiveness of treatment options in end-stage heart failure with atrial fibrillation is crucial for healthcare decision-making, particularly in resource-limited settings. This study provides evidence that catheter ablation combined with GDMT is a financially viable option.

Source

PubMed · PMID 42162774

Published in Heart Rhythm. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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