Quality of life in schizophrenia: Symptomatic markers of improvement over time.

Psychiatr Rehabil JMay 18, 2026 (epub)
Clinical ResearchPsychiatryOpen access

Samuel M Murphy, Ana T Flores, Deepak K Sarpal et al.

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In 30 seconds

This randomized controlled trial examined the relationship between symptom severity and quality of life (QoL) in 102 individuals with schizophrenia spectrum disorders over 18 months. Results indicated that improvements in total and psychological QoL were observed, with older individuals showing less improvement. Increased affective symptoms were linked to poorer QoL across multiple domains.

Key findings

  • Improvements in total and psychological QoL were observed over time across treatment groups.
  • Older individuals showed smaller QoL improvements compared to younger participants.
  • Increased affective symptomatology predicted diminished QoL in total, physical, psychological, and social domains.
  • Increased positive symptomatology was linked to poorer social relationships and environmental QoL.

Why it matters

Understanding the impact of symptom severity on QoL can guide clinicians in developing targeted interventions. Addressing affective symptoms may enhance QoL outcomes, particularly in younger patients, highlighting the need for tailored therapeutic approaches.

Source

PubMed · PMID 42149541Free full text on PubMed Central

Published in Psychiatr Rehabil J. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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