A Randomized Clinical Trial to Compare Moxifloxacin Versus Azithromycin for the Treatment of Mycoplasma genitalium: The FARTHEST Study.

Clin Infect DisSep 2, 2026
Clinical ResearchInfectious DiseasesObstetrics & Gynecology

Roberto Rossotti, Chiara Baiguera, Davide Paolo Bernasconi et al.

✦ AI-curated · Sources linked

In 30 seconds

This randomized controlled trial evaluated the efficacy of moxifloxacin versus azithromycin for treating Mycoplasma genitalium in adults. Among 358 participants, 87.0% of those receiving moxifloxacin achieved microbiological cure compared to 61.2% for azithromycin, resulting in an absolute risk difference of 25.8%. Moxifloxacin was superior across most subgroups.

Key findings

  • 87.0% of moxifloxacin recipients achieved microbiological cure compared to 61.2% for azithromycin.
  • The absolute risk difference in microbiological cure was 25.8% (95% CI 16.5, 35.2).
  • Moxifloxacin was superior in efficacy across most subgroups analyzed.
  • Both treatment regimens were well tolerated with minimal discontinuation.

Why it matters

The study provides evidence supporting moxifloxacin as a more effective treatment option for Mycoplasma genitalium infections, particularly in settings where resistance testing is not available. This could influence treatment guidelines and clinical decision-making.

Source

PubMed · PMID 42142880

Published in Clin Infect Dis. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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