Efficacy of combined supplementation of vitamins A/D/K1/K2 on the growth and development of preterm infants: A randomized controlled trial.

Nutr Clin PractMay 13, 2026 (epub)
Clinical ResearchPediatricsEndocrinology

Yuanyuan Ding, Huiyan Du

✦ AI-curated · Sources linked

In 30 seconds

This randomized controlled trial investigated the effects of combined supplementation of vitamins A and K2 on the growth and skeletal development of 86 preterm infants. The intervention group, receiving additional vitamins A and K2, showed significant improvements in bone mineral density and height standard deviation score after 12 months compared to the control group.

Key findings

  • The intervention group had higher lumbar spine and femur BMD after 12 months.
  • Greater height standard deviation score (HtSDS) was observed in the intervention group.
  • Serum levels of vitamins A, D, K1, K2, and 25-OH-D were significantly higher in the intervention group.
  • No significant difference in adverse reactions was noted between the two groups.

Why it matters

The findings suggest that additional supplementation of vitamins A and K2 can enhance skeletal development and micronutrient status in preterm infants, which is crucial for their growth and long-term health outcomes.

Source

PubMed · PMID 42125969

Published in Nutr Clin Pract. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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