Attenuating trauma- and cocaine-related intrusions by blocking memory reconsolidation with minocycline: protocol for a transdiagnostic randomized controlled trial.

Eur J PsychotraumatolMay 12, 2026 (epub)
Clinical ResearchPsychiatryOpen access

Lina Dietiker, Amelie Zacher, Sofia de'Sperati et al.

✦ AI-curated · Sources linked

In 30 seconds

This randomized controlled trial investigates the effects of minocycline, an MMP-9 inhibitor, on intrusive memories in individuals with PTSD and cocaine use disorder. A total of 120 participants (60 with PTSD and 60 with cocaine use disorder) will receive either minocycline or placebo before reactivating their intrusive memories. The study aims to assess changes in memory-related mechanisms and neurobiological correlates.

Key findings

  • Participants will receive a single dose of minocycline or placebo prior to memory reactivation.
  • Intrusive memories will be assessed using ecological momentary assessment and pre-post questionnaires.
  • Neurobiological correlates will be measured through fMRI, MRS, and peripheral biomarkers.
  • The trial aims to inform future memory-focused interventions for trauma and addiction.

Why it matters

Understanding the mechanisms underlying intrusive memories in PTSD and substance use disorders can enhance treatment strategies. This study may provide insights into pharmacological interventions that target maladaptive memory processes, potentially improving outcomes for affected individuals.

Source

PubMed · PMID 42117362Free full text on PubMed Central

Published in Eur J Psychotraumatol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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