Comparison of the clinical efficacy, safety and EEG functional connectivity changes between 18-Hz rTMS and iTBS of accelerated dTMS treatment for major depressive disorder: a randomized controlled trial.

Mol PsychiatryMay 11, 2026 (epub)
Clinical ResearchPsychiatryOpen access

Lulu Yang, Haiyue Dai, Mingjie Zhu et al.

✦ AI-curated · Sources linked

In 30 seconds

This randomized controlled trial compared the efficacy and safety of 18-Hz rTMS and iTBS of accelerated dTMS in 73 patients with major depressive disorder (MDD). Both dTMS protocols significantly reduced Hamilton Depression Rating Scale (HAMD) scores, with the iTBS-dTMS group showing a decrease from 22.5 ± 3.7 to 8.2 ± 4.1, and a treatment response rate of 85.7%.

Key findings

  • iTBS-dTMS group had a HAMD score reduction from 22.5 ± 3.7 to 8.2 ± 4.1.
  • rTMS-dTMS group showed a HAMD score decrease from 21.3 ± 2.9 to 8.0 ± 3.8.
  • Treatment response rate was 85.7% for iTBS-dTMS compared to 76.9% for rTMS-dTMS.
  • Remission rates were 50.0% for iTBS-dTMS and 42.3% for rTMS-dTMS, significantly higher than 10.5% for the drug group.

Why it matters

The study highlights the potential of accelerated dTMS protocols, particularly iTBS, as effective treatments for MDD, offering improved response and remission rates compared to traditional pharmacotherapy. This could enhance treatment options for patients with depression.

Source

PubMed · PMID 42115366Free full text on PubMed Central

Published in Mol Psychiatry. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

ShareTelegramLinkedIn

AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

More in Psychiatry

Clinical ResearchPreventive Medicine / Public Health

2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines.

This systematic review and practice guideline, developed by a multidisciplinary panel using NUTRIGRADE, assessed Mediterranean diet evidence across nine health domains and one economic domain.

Nutr RevNov 12, 2026Read summary
Clinical ResearchOrthopedic Surgery

Prevention of Venous Thromboembolism after Total Hip or Knee Replacement.

This multicenter randomized comparative-effectiveness noninferiority trial compared 30 days of aspirin, warfarin, or rivaroxaban for VTE prophylaxis after elective total hip or knee arthroplasty.

N Engl J MedNov 12, 2026Read summary
Clinical ResearchAnesthesiology

Effect of discontinuing antihypertensives on perioperative hypotension in older patients before non-cardiac surgery: multicentre, randomised, double blind, controlled trial.

This multicentre, randomised, double blind, placebo controlled trial assessed whether withholding ACE inhibitors or ARBs on the morning of surgery reduces perioperative hypotension in older adults undergoing non-cardiac…

BMJNov 11, 2026Read summary

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.