Effect of omega-3 supplementation vs. placebo on blood lipid levels in patients with ischemic heart disease: a systematic review and meta-analysis.

Nutr Metab Cardiovasc DisApr 16, 2026 (epub)
Clinical ResearchCardiology

Ammar Yasser Negm, Abdullah Samir Ashour, Mustafa Youssef Mohamed et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review and meta-analysis evaluated the effects of omega-3 supplementation on lipid profiles in patients with ischemic heart disease (IHD). Analyzing data from ten randomized controlled trials involving 633 participants, the study found that omega-3 significantly reduced triglycerides by 17.53 mg/dL and LDL-C by 9.43 mg/dL, suggesting its potential role in managing dyslipidemia in IHD patients.

Key findings

  • Omega-3 supplementation reduced triglycerides by 17.53 mg/dL (95% CI: -30.64 to -4.41; p = 0.009).
  • LDL-C levels decreased by 9.43 mg/dL (95% CI: -14.20 to -4.65; p = 0.0001).
  • A trend towards total cholesterol reduction was observed (MD: -6.03 mg/dL, p = 0.05).
  • HDL-C increased by 1.66 mg/dL post-sensitivity analysis (p = 0.03).

Why it matters

The findings highlight the potential of omega-3 fatty acids as an adjunctive therapy for managing lipid levels in patients with ischemic heart disease, particularly in those who do not achieve optimal lipid control with statins alone.

Source

PubMed · PMID 42115081

Published in Nutr Metab Cardiovasc Dis. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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