Short-term outcomes of ticagrelor monotherapy after primary percutaneous coronary intervention for ST-elevation myocardial infarction: A randomized pilot study.

Am Heart JApr 28, 2026 (epub)
Clinical ResearchCardiology

Eva C I Woelders, Bahram Yosofi, Denise A M Peeters et al.

✦ AI-curated · Sources linked

In 30 seconds

This randomized pilot study evaluated the safety of ticagrelor monotherapy compared to ticagrelor plus aspirin in 200 STEMI patients after primary PCI. At 3 months, major adverse cardiac and cerebral events occurred in 3.1% of the ticagrelor group versus 2.0% in the control group, with no significant difference in ischemic events.

Key findings

  • Major adverse cardiac and cerebral events occurred in 3.1% of the ticagrelor group vs 2.0% in the control group.
  • Clinically relevant bleeding was observed in 4.2% of the ticagrelor group vs 8.9% in the control group.
  • Clinically relevant non-access site bleeding was 2.0% in the ticagrelor group vs 7.9% in the control group.

Why it matters

Understanding the safety profile of ticagrelor monotherapy could inform treatment strategies post-PCI, particularly in reducing bleeding risks associated with dual antiplatelet therapy in STEMI patients.

Source

PubMed · PMID 42061600

Published in Am Heart J. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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