Cognitive function and anticoagulation discontinuation in patients without long-term recurrence after catheter ablation for atrial fibrillation: A substudy of the ALONE-AF trial.

Heart RhythmApr 24, 2026 (epub)
Clinical ResearchCardiology

Ho-Gi Chung, Il-Young Oh, Jun Kim et al.

✦ AI-curated · Sources linked

In 30 seconds

This substudy of the ALONE-AF trial evaluated the cognitive effects of oral anticoagulant (OAC) discontinuation in patients aged 19-80 years without atrial fibrillation recurrence after catheter ablation. The randomized controlled trial found no significant difference in cognitive decline between those who discontinued OAC and those who continued, with a between-group difference in MoCA score change of 0.1.

Key findings

  • Mean total MoCA score increased from 24.4 to 25.0 in the no-OAC group.
  • Mean total MoCA score increased from 24.2 to 24.9 in the OAC group.
  • No significant difference in cognitive score change between no-OAC and OAC groups (P = .759).

Why it matters

Understanding the cognitive implications of OAC therapy discontinuation in patients post-ablation is crucial for managing long-term care and stroke risk. This study suggests that discontinuation may not adversely affect cognitive function in this population.

Source

PubMed · PMID 42035938

Published in Heart Rhythm. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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