The influence of C-reactive protein on depression in inflammatory bowel disease: A systematic review and meta-analysis.

J Affect DisordApr 24, 2026 (epub)
Clinical ResearchGastroenterologyPsychiatry

Yidan Cheng, Meifen Song, Pingyang Xu et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review and meta-analysis examined the relationship between C-reactive protein (CRP) levels and depression in patients with inflammatory bowel disease (IBD). Analyzing data from 10 case-control studies with 2105 participants, it was found that IBD patients with depression had significantly higher CRP levels than non-depressed patients (SMD = 0.18, 95% CI: 0.09-0.27).

Key findings

  • IBD patients with depression had significantly higher CRP levels than non-depressed patients (SMD = 0.18, 95% CI: 0.09-0.27).
  • The association was more pronounced in the Asian region (SMD = 0.26, 95% CI: 0.11-0.41).
  • In patients aged ≤40 years, the association was stronger (SMD = 0.27, 95% CI: 0.15-0.39).
  • Higher CRP levels were linked to a greater likelihood of depression in IBD patients.

Why it matters

Understanding the link between CRP levels and depression in IBD patients can aid clinicians in identifying those at higher risk for depression, potentially leading to improved management strategies for this comorbidity.

Source

PubMed · PMID 42035803

Published in J Affect Disord. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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