Rationale and design of the vericiguat in vasospastic angina (ViVA) trial: A double-blind placebo-controlled randomized cross-over study.

Am Heart JApr 23, 2026 (epub)
Clinical ResearchCardiology

Hanae F Namba, Elize A M de Jong, Coen K M Boerhout et al.

✦ AI-curated · Sources linked

In 30 seconds

The Vericiguat in Vasospastic Angina (ViVA) trial is a double-blind, placebo-controlled randomized cross-over study investigating the effects of vericiguat on patients with angina and no obstructive coronary arteries (ANOCA). The study aims to evaluate vericiguat's impact on endothelial function, microvascular vasodilator responses, angina frequency, and quality of life in 50 patients.

Key findings

  • The trial will include 50 patients with ANOCA.
  • Patients will be randomized in a 1:1 ratio to receive either placebo or vericiguat first.
  • Vericiguat is hypothesized to reduce coronary spasm episodes.

Why it matters

Understanding the effects of vericiguat on coronary vasospasm could provide new therapeutic options for patients with ANOCA, a condition often challenging to manage due to the absence of obstructive coronary disease.

Source

PubMed · PMID 42034271

Published in Am Heart J. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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