Analgesic Effects of Intravenous Lidocaine in Laparoscopic Surgery: A Systematic Review and Meta-Analysis With Trial Sequential Analysis.
Ka T Ng, Wei E Lim, Wan Y Teoh et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effects of intravenous lidocaine on postoperative pain in adults undergoing laparoscopic surgery, including 45 randomized clinical trials with 2599 patients. The study found that intravenous lidocaine significantly reduced postoperative pain scores at rest (MD: -0.27) and during movement (MD: -0.58), as well as decreased opioid consumption and nausea incidence.
Key findings
- Intravenous lidocaine reduced postoperative pain scores at rest by MD: -0.27.
- During movement, pain scores decreased significantly with MD: -0.58.
- Fentanyl consumption was reduced by MD: -14.46 postoperatively.
- The incidence of nausea and vomiting was lowered with RR: 0.66.
Why it matters
The findings suggest that intravenous lidocaine can be an effective component of multimodal analgesia, potentially improving postoperative recovery by reducing pain and opioid use, which may enhance patient outcomes and satisfaction.
What to keep in mind
The findings should be interpreted with caution due to low evidence quality and high heterogeneity among the included studies.