"Et tu, Brute?" - A Case of Ixazomib - Induced Cancer Therapy-related Cardiac Dysfunction.

Intern MedFeb 24, 2026 (epub)
Case ReportCardiologyOncology (Medical)

Yusuke Hirao, Kensuke Matsumoto, Yu Mizutani et al.

✦ AI-curated · Sources linked

Case in brief

An 81-year-old man with multiple myeloma presented with decompensated heart failure. His left ventricular ejection fraction (LVEF) had been preserved at baseline but fell to 35% 13 months after starting ixazomib. The temporal relationship, previously normal echocardiography, and multimodal imaging findings led clinicians to strongly suspect ixazomib-induced cancer therapy-related cardiac dysfunction. Ixazomib was discontinued and guideline-directed medical therapy continued, but his LVEF had not recovered at the time of reporting.

What made this case unusual

The suspected ixazomib-related cardiac dysfunction remained irreversible despite stopping the drug and continuing guideline-directed medical therapy.

Diagnostic / clinical pearl

A substantial decline in LVEF after ixazomib exposure, considered alongside prior normal echocardiography and multimodal imaging, can support suspicion of treatment-related cardiac dysfunction.

Source

PubMed · PMID 41730625

Published in Intern Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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