Synchronous diagnosis of multicentric glioma with distinct isocitrate dehydrogenase molecular profiles: a case report.

CNS OncolFeb 12, 2026 (epub)
Case ReportOncology (Medical)NeurologyOpen access

Aditya A Mohan, Kristen Batich, Shih-Hsiu J Wang et al.

✦ AI-curated · Sources linked

Case in brief

A 28-year-old woman presented with dizziness, retro-orbital pain, headache, and right-arm numbness and paresthesia. MRI showed two non-enhancing T2/FLAIR-hyperintense lesions in the left frontal and parietal lobes. Histopathology and molecular testing, including whole-exome sequencing, identified a grade 2 oligodendroglioma with an IDH1 R132S mutation in the frontal lobe and a grade 4 astrocytoma with an IDH1 R132H mutation in the parietal lobe. Their distinct profiles supported consideration of each synchronous tumor as an individual primary when planning treatment.

What made this case unusual

The synchronous lesions had different histologic diagnoses and distinct IDH1 mutations, supporting separate primary tumors rather than spread from one tumor to the other.

Diagnostic / clinical pearl

When synchronous brain lesions differ in appearance or suspected tumor type, analyze each lesion individually; distinct histologic and molecular profiles can clarify whether they represent separate primary tumors.

Source

PubMed · PMID 41674328Free full text on PubMed Central

Published in CNS Oncol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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