COVID-19 and Neonatal Guillain-Barré Syndrome: Exploring a Possible Causal Link With Review of Literature.

J Child NeurolFeb 6, 2026 (epub)
Case ReportPediatricsNeurology

Choudri Muzafar Paswal, Neeraj Gupta, Swasthi Kabi Satpathy et al.

✦ AI-curated · Sources linked

Case in brief

A 24-day-old term male developed progressive hypotonia, weak cry, and respiratory distress after a febrile illness with gastrointestinal symptoms. Examination showed areflexia, cranial nerve involvement, and generalised weakness. Cerebrospinal fluid demonstrated albuminocytologic dissociation, MRI showed cauda equina enhancement, and nerve conduction studies identified motor-sensory polyneuropathy, supporting Guillain-Barré syndrome. Anti-SARS-CoV-2 IgG was high (>4000 IU/mL), while maternal titres were negative. Following two courses of intravenous immunoglobulin, he recovered fully and was developmentally normal at 2-year follow-up.

What made this case unusual

The report describes postnatally acquired neonatal Guillain-Barré syndrome potentially associated with SARS-CoV-2, with high infant anti-SARS-CoV-2 IgG and negative maternal titres.

Diagnostic / clinical pearl

Consider Guillain-Barré syndrome in a floppy neonate with a postinfectious presentation; areflexia and supportive cerebrospinal fluid, imaging, and nerve conduction findings can help establish the diagnosis.

Source

PubMed · PMID 41649968

Published in J Child Neurol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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