Association Between Vitamin D Status and Nocturnal Lower Urinary Tract Symptoms: A Pooled Analysis.
Zihan Ye, Hongsong Chen, Qiang Zhang et al.
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In 30 seconds
This systematic review and meta-analysis assessed associations between vitamin D status or intake and nocturnal lower urinary tract symptoms (nLUTS), drawing on 17 studies: 5 randomised trials, 2 cohort studies, 4 cross-sectional studies, and 6 case-control studies. Vitamin D deficiency (<20 ng mL-1) was associated with 4.86-fold higher odds of nLUTS, while mean serum 25-hydroxyvitamin D was 7.75 ng mL-1 lower among people with nLUTS than controls. Supplementation correlated with an 86% relative risk reduction and 0.23 fewer nocturnal voids per night; the authors note stronger associations in children and people with nocturnal polyuria.
Key findings
- Vitamin D deficiency (<20 ng mL-1) was associated with a 4.86-fold increase in the odds of nLUTS.
- Mean serum 25-hydroxyvitamin D was 7.75 ng mL-1 lower in participants with nLUTS than in controls.
- Vitamin D supplementation correlated with an 86% relative risk reduction for nLUTS and 0.23 fewer nocturnal voids per night.
- Associations were stronger in pediatric populations and patients with nocturnal polyuria.
Why it matters
The pooled findings link vitamin D status with nLUTS and suggest that deficiency may identify a group with greater symptom burden. The reported supplementation associations are potentially relevant to symptom management, but the evidence combines observational studies and randomised trials, so the results should not be interpreted as establishing a causal treatment effect.
What to keep in mind
The review combines diverse designs, including observational studies and randomised trials; the abstract does not report study-level heterogeneity or the certainty of evidence.