Sustained Virologic Response Following a Shortened Course of Direct-Acting Antiviral Therapy in an HIV/HCV Co-Infected Patient With Previous Treatment Experience: A Case Report.

J Pharm PractDec 19, 2025 (epub)
Case ReportInfectious DiseasesGastroenterology

Natasha Bhutani, Yoona Lee, Maria A Longo et al.

✦ AI-curated · Sources linked

Case in brief

A 47-year-old treatment-experienced man with HIV and chronic HCV had completed 10 weeks of sofosbuvir-velpatasvir before starting sofosbuvir-velpatasvir-voxilaprevir. He took the triple regimen for approximately 4 weeks, then was lost to follow-up for 3 months. HCV testing showed sustained virologic response 12 weeks after treatment (SVR12), despite the shortened course. The report highlights that virologic response was documented after incomplete triple-direct-acting antiviral therapy in this individual.

What made this case unusual

SVR12 followed approximately 4 weeks of triple therapy in a treatment-experienced patient who had already received 10 weeks of sofosbuvir-velpatasvir.

Diagnostic / clinical pearl

For patients lost to follow-up or who did not complete HCV therapy, assess HCV RNA for SVR12 before considering treatment re-initiation.

Source

PubMed · PMID 41420270

Published in J Pharm Pract. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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