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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

AllClinical ResearchCase Reports
FeaturedCase ReportRheumatology

Rheumatoid factor positivity in ANCA-negative eosinophilic granulomatosis with polyangiitis: cardiac mimicry, mononeuritis multiplex, and long-term outcome in a case-based systematic review.

Rheumatol IntNov 10, 2026Open access

A 42-year-old woman with long-standing asthma and rheumatoid factor (RF) of 322 IU/mL presented with myocardial infarction-like cardiac involvement despite non-obstructive coronary arteries.

Clinical pearl

High RF positivity does not exclude EGPA. In a patient with asthma, eosinophilia, and compatible ENT, neurologic, or cardiac manifestations, consider EGPA even when ANCA is negative and RF is elevated.

Read case

Also worth knowing

Case ReportInfectious DiseasesOpen access

Multidisciplinary management of disseminated tuberculosis with tuberculous meningitis and active hepatitis B in a critically ill pregnant woman in the third trimester: a case report.

A 24-year-old woman at 30 weeks’ gestation presented with headache, vomiting, fever, and nuchal rigidity. Cerebrospinal fluid findings confirmed tuberculous meningitis, and chest CT showed diffuse miliary nodules…

Infect Dis PovertyNov 10, 2026Read case
Case ReportOncology (Medical)

Successful rechallenge with almonertinib and corticosteroids after gefitinib-induced interstitial lung disease: A case report and literature review.

A 53-year-old never-smoking woman with stage IV, EGFR L858R-mutant lung adenocarcinoma developed progressive dyspnea and hypoxemia after two months of gefitinib, despite an initial tumor response.

Medicine (Baltimore)Nov 6, 2026Read case
Case ReportHematology

IgD-λ POEMS syndrome presenting with edema, pulmonary hypertension, and renal impairment: A case report.

A 38-year-old woman presented with years of intermittent leg edema, elevated creatinine, and acute worsening, followed by precapillary pulmonary hypertension, polyserous effusions, splenomegaly, lymphadenopathy, anemia…

Medicine (Baltimore)Nov 6, 2026Read case
Case ReportOncology (Medical)

Postoperative Neuromuscular Paresis and Overlap Syndrome Related to Immune Checkpoint Inhibitors: A Case Report.

A patient receiving immune checkpoint inhibitor therapy developed extremity paresis after proximal humerus resection and reconstruction.

JBJS Case ConnectNov 5, 2026Read case
Case ReportRheumatologyOpen access

Pulmonary-Cardiac Involvement in a Patient with IgA Vasculitis.

A 41-year-old woman with biopsy-proven IgA nephropathy presented with progressive dyspnea, hemoptysis, and a painful purpuric rash.

Methodist Debakey Cardiovasc JNov 3, 2026Read case
Case ReportMedical GeneticsOpen access

"Fatal venous thromboembolism and divergent phenotypes in DOCK8 deficiency: a three-sibling case series".

Three siblings with genetically confirmed DOCK8 deficiency had early-onset atopic dermatitis, recurrent respiratory infections, and failure to thrive. All developed bronchiectasis and severe viral infections.

Immunol ResNov 3, 2026Read case
Case ReportPathology (Anatomic & Clinical)Open access

Non-Small Cell Lung Carcinoma With Bilayered Architecture and TP53 Alteration: A Diagnostic Pitfall and a Potential Distinct Entity.

A 75-year-old never-smoker had a 1.1-cm pulmonary nodule with an intact bilayered architecture, including a continuous basal cell layer.

Thorac CancerNov 1, 2026Read case
Case ReportRheumatologyOpen access

Severe ARDS and secondary haemophagocytic lymphohistiocytosis complicating a flare of adult-onset Still's disease: a case-based review.

A 42-year-old woman with adult-onset Still’s disease (AOSD) developed a flare after a five-week interruption of conventional synthetic disease-modifying therapy around surgery for a perianal abscess with fistulous…

Rheumatol IntOct 31, 2026Read case
Case ReportNephrology

Acute kidney injury after aminoglycoside exposure in two cystic fibrosis patients receiving triple CFTR modulator therapy.

Two patients with cystic fibrosis developed acute kidney injury after their first aminoglycoside exposure while receiving triple CFTR modulator therapy.

J NephrolOct 30, 2026Read case
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