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845 articles
November 202624
Coracoid Process Osteochondroma: Diagnostic Considerations and Detailed Approach for Management: Case Report and Literature Review.
A 21-year-old woman was found to have an osteochondroma arising from the tip of the coracoid process. The report describes preoperative clinical assessment and radiological investigation, with histopathological…
Postoperative Tumor-Informed Circulating Tumor DNA Status for Molecular Residual Disease Detection After Curative-Intent Resection of Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled observational evidence on postoperative tumor-informed circulating tumor DNA (ctDNA) as a marker of molecular residual disease after curative-intent resection of…
Polyamine Dysregulation in Metabolic Dysfunction-associated Steatotic Liver Disease: a Systematic Review of Human Observational Evidence.
This systematic review evaluated human observational evidence linking polyamines with MASLD severity and related hepatic or metabolic outcomes.
Measles-like hypermutation of a Newcastle disease virus drives fatal encephalitis during BCMA × CD3 T-cell-redirecting immunotherapy.
A patient with multiple myeloma receiving maintenance teclistamab, daratumumab, and lenalidomide developed rapidly progressive brainstem-cerebellar encephalitis.
Primary Synovial Sarcoma of the Thyroid Gland Presenting With Early Pulmonary Metastasis: Diagnostic Pathway, SS18 Gene Fusion Confirmation, and Clinical Course.
A 47-year-old woman presented with dysphagia and a left-sided neck mass. Initial fine-needle aspiration was non-diagnostic; repeat sampling suggested a spindle cell neoplasm.
Diagnostic yield and early outcomes of radical prostatectomy without prior histopathologic diagnosis: a single-arm systematic review and meta-analysis.
This single-arm systematic review and random-effects meta-analysis assessed radical prostatectomy without prior histopathologic confirmation in adult men with high clinical suspicion of clinically significant prostate…
Spatial transcriptomics tumor microenvironment determinants of tyrosine kinase inhibitor response in renal cell carcinoma: results from a phase 2 clinical trial.
This phase 2 clinical trial examined whether spatially resolved tumor gene-expression patterns were associated with sunitinib response in 46 patients with metastatic clear cell renal cell carcinoma.
The characteristics of men who have sex with men presenting with oral syphilis: a systematic review.
This systematic review described demographic, behavioural, co-infection and clinical features of men who have sex with men (MSM) presenting with oral syphilis.
Molecular Diagnostics and Clinicopathologic Spectrum of Kinase Fusion-Positive Spindle Cell Neoplasms of the Oral and Maxillofacial Region: A Systematic Review and Pooled Patient-Level Analysis.
This systematic review and pooled patient-level analysis characterized kinase fusion-positive spindle cell neoplasms of the oral and maxillofacial region using published reports.
Multifocal intradural extramedullary myxopapillary ependymoma of the spine.
A 34-year-old man presented with sudden severe non-radicular low-back pain but no neurological deficit. MRI showed multiple enhancing intradural extramedullary lesions from T12-L1 to S1; the dominant T12-L1 lesion…
Progression-Associated Loss of SMARCB1/INI1 Expression in Mismatch Repair-Deficient Glioblastoma.
A patient with mismatch repair-deficient glioblastoma had a recurrent tumor in which testing identified a second SMARCB1 mutation and complete loss of SMARCB1/INI1 protein expression.
Adrenal ganglioneuroma in an adolescent presenting as an incidentaloma: Imaging-pathology correlation and diagnostic challenges: A case report.
A previously healthy 16-year-old male had a right adrenal mass discovered incidentally on CT after a bicycle accident. CT and MRI showed a well-circumscribed lesion with progressive enhancement and no washout or…
Pulmonary sarcomatoid carcinoma with METex14 mutation and high PD-L1: A case report.
A previously healthy 54-year-old man presented with persistent cough and diminished breath sounds over the right upper lung.
Glucocorticoid therapy for acute interstitial nephritis in a patient with diabetic nephropathy: A case report.
A 41-year-old man with diabetes and hypertension developed acute kidney dysfunction after previously normal renal function; he had used an unidentified herbal decoction during the preceding month.
Primary splenic angiosarcoma initially diagnosed as littoral cell angioma: A case report of a diagnostic pitfall.
A 71-year-old woman presented with left upper abdominal pain, severe anemia, thrombocytopenia, and a splenic lesion. After splenectomy, the lesion was initially diagnosed as littoral cell angioma; a separate hepatic…
Prognostic value of anti-gp210 antibodies in primary biliary cholangitis: A Systematic review and meta-analysis.
This systematic review and meta-analysis pooled evidence from 12 records examining the prognostic significance of anti-gp210 antibodies in people with primary biliary cholangitis (PBC).
Synchronous hepatocellular carcinoma and nasopharyngeal carcinoma in a patient with chronic hepatitis B: A case report and literature review.
A 63-year-old Chinese man with chronic hepatitis B was found on routine screening to have a liver mass and reported nasal obstruction.
Bone marrow sarcoidosis in Takayasu arteritis: Case report and literature review.
A 46-year-old woman with confirmed Takayasu arteritis presented with elevated systemic inflammatory markers and diffuse hypermetabolic activity on PET.
IgD-λ POEMS syndrome presenting with edema, pulmonary hypertension, and renal impairment: A case report.
A 38-year-old woman presented with years of intermittent leg edema, elevated creatinine, and acute worsening, followed by precapillary pulmonary hypertension, polyserous effusions, splenomegaly, lymphadenopathy, anemia…
Assay-aware flow-cytometric interpretation of relapsed B-cell precursor acute lymphoblastic leukemia after sequential CD19- and CD22-directed therapy: A case report.
A 73-year-old woman with B-cell precursor acute lymphoblastic leukemia developed marrow relapse after blinatumomab exposure.
Intestinal tuberculosis with multiple intestinal perforations in a 5-month-old infant: The role of metagenomic next-generation sequencing: a case report and literature review.
A 5-month-old boy presented with fever and abdominal distension that progressed to intestinal obstruction and multiple perforations involving the distal ileum and appendiceal region.
Curriculum-Aligned Conversational AI to Support Pathology Self-Directed Learning in Preclinical Medical Students: Crossover Randomized Pilot Study.
This crossover randomized pilot study evaluated a curriculum-aligned custom GPT for self-directed pathology learning among 44 second-year medical students at the University of South Carolina, Floyd School of Medicine.
A case report of ultra-rare SMARCD2 deficiency and review of the literature.
The report describes a patient with congenital neutropenia due to specific granule deficiency type 2, a syndromic autosomal recessive disorder associated with loss-of-function variants in SMARCD2.
Recovery after more than one month of dialysis in legionella-associated acute kidney injury: a case evaluated with gallium-67 scintigraphy and renal biopsy.
A 73-year-old man developed dialysis-dependent acute kidney injury during severe Legionella pneumonia. Although the infection resolved and antibiotics had been stopped, kidney injury persisted for more than a month.
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