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784 articles
November 202624
2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines.
This systematic review and practice guideline, developed by a multidisciplinary panel using NUTRIGRADE, assessed Mediterranean diet evidence across nine health domains and one economic domain.
Is Exercise Effective at Reducing Pain Catastrophizing in People With Chronic Nonspecific Spinal Pain? A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined whether exercise reduces pain catastrophizing in people with chronic nonspecific spinal pain.
Cutaneous Silent Period-Based Comparison of Dorsal Root Ganglion Pulsed Radiofrequency and Transforaminal Epidural Steroid Injection in Lumbar Radicular Pain: A Randomized Controlled Trial.
This prospective, single-blind randomized controlled trial compared dorsal root ganglion pulsed radiofrequency (DRG-PRF) with transforaminal epidural steroid injection (TFESI) in 36 patients with chronic unilateral…
Cardiovascular disease and stroke prevention educational-behavioural programmes for culturally and/or linguistically diverse communities: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed cardiovascular disease (CVD) and stroke prevention educational-behavioural programmes for people from culturally and/or linguistically diverse (CALD) backgrounds.
Efficacy and safety of selective orexin 2 receptor agonists in narcolepsy type 1: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis pooled randomized, double-blind, placebo-controlled trials of oral selective orexin 2 receptor agonists in people with narcolepsy type 1.
XR serious games for phantom limb pain, neurofunctional recovery, and prosthetic adoption: a systematic review.
This systematic review synthesized studies of extended-reality serious games for adults with limb amputation, examining phantom limb pain, rehabilitation, embodiment, and prosthesis adoption.
Severity-Based Triage for Direct Transportation to Nearest Comprehensive Stroke Center: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed prehospital bypass of the nearest stroke center for direct transport to a more distant comprehensive stroke center in patients with suspected stroke.
Loberamisal for Acute Ischemic Stroke: The LAIS Randomized Clinical Trial.
The LAIS trial was a multicenter, double-blind, randomized, placebo-controlled phase 3 study at 32 hospitals in China. It enrolled adults aged 18 to 80 years with acute ischemic stroke, treated within 48 hours, and…
Brain MRI changes following continuous positive airway pressure therapy in adults with obstructive sleep apnea: a systematic review.
This systematic review synthesized longitudinal brain MRI studies in adults with obstructive sleep apnea (OSA) before and after continuous positive airway pressure (CPAP), including comparisons with control groups.
Slow-wave sleep mediates the compensatory effects of acute moderate-intensity exercise on declarative memory deficits in sleep restriction.
This randomized controlled trial tested whether one session of moderate-intensity exercise could protect declarative memory during sleep restriction and whether slow-wave sleep (SWS) mediated any benefit.
Effectiveness of guided internet-delivered cognitive behavioral therapy for insomnia in autistic adults (i-Sleep Autism): a randomized controlled trial.
This randomized controlled trial evaluated a 5-week, guided internet-delivered cognitive behavioral therapy intervention adapted for autistic adults with insomnia.
Sex Differences in Blood Pressure Dynamics and Outcomes After Endovascular Thrombectomy.
This exploratory secondary analysis of the multicenter, open-label, blinded-end-point ENCHANTED2/MT randomized trial examined sex differences in blood pressure (BP) and outcomes among adults with acute ischemic stroke…
Vitamin D status and chemotherapy-induced peripheral neuropathy in patients with cancer: a systematic review with exploratory quantitative synthesis.
This systematic review with exploratory quantitative synthesis assessed whether serum or plasma 25-hydroxyvitamin D status was associated with chemotherapy-induced peripheral neuropathy (CIPN) in patients receiving…
Impact of Particulate Matter Exposure on Neurological Health in Older Adults: A Systematic Review.
This PRISMA-guided systematic review assessed epidemiological evidence linking particulate matter (PM) exposure with neurological health in older adults.
Testing the EQ-HWB-9 with seven-day versus today recall periods in dementia: variability and recall adherence under health fluctuations.
This mixed-methods randomized study compared “7-day” and “today” EQ-HWB-9 recall periods in people living with dementia and caregiver dyads recruited from German primary care.
Subsequent epilepsy surgery after SEEG-guided radiofrequency thermocoagulation: Outcomes and prognostic value of treatment response-a systematic review and meta-analysis.
This systematic review and meta-analysis assessed outcomes after resective, disconnective, or ablative epilepsy surgery in patients previously treated with SEEG-guided radiofrequency thermocoagulation (SEEG-RFTC), and…
Optimal duration of levetiracetam prophylaxis following supratentorial tumor resection: a multi-study analysis.
This systematic review and meta-analysis compared short-course (≤ 9 days) with extended-course (> 9 days) levetiracetam prophylaxis in seizure-naïve patients after supratentorial tumor resection.
Intra-arterial tenecteplase for acute basilar artery occlusion with sufficient recanalization after thrombectomy: the INSIST-IT randomized clinical trial.
The INSIST-IT multicentre, prospective, randomised trial assessed adjunctive intra-arterial tenecteplase after successful endovascular reperfusion in patients with acute basilar artery occlusion treated within 24 hours…
Intra-arterial tenecteplase during thrombectomy for acute ischemic stroke: the BRETIS-TNK2 trial.
The phase 3 BRETIS-TNK2 multicentre randomised trial compared intra-arterial tenecteplase during endovascular thrombectomy with thrombectomy alone in patients with large-vessel occlusion eligible for treatment within 24…
Rescue treatment for medium vessel occlusion by intra-arterial tenecteplase: the RESCUE-TNK randomized clinical trial.
The RESCUE-TNK phase 2, multicentre randomised trial evaluated intra-arterial tenecteplase versus standard care in patients with acute ischaemic stroke caused by medium vessel occlusion.
Feasibility and tolerability of combining 6 Hz transcranial alternating current stimulation (tACS) at 3.2 mA and digital cognitive training in older adults with mild cognitive impairment.
This randomized-trial study evaluated feasibility and tolerability of five daily sessions of 6-Hz, 3.2-mA transcranial alternating current stimulation (tACS) during digital cognitive training (DCT) in older adults with…
Efficacy of cognitive behavioral therapy for anxiety and depression symptoms in Parkinson's disease patients: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed cognitive behavioral therapy (CBT) for anxiety and depressive symptoms in adults with Parkinson’s disease (PD), pooling 21 randomized controlled trials involving 892…
Salovum® reduces mortality in isolated severe traumatic brain injury: a randomized phase II trial.
This prospective, double-blind, placebo-controlled phase II randomized trial tested Salovum® in adults with isolated severe traumatic brain injury receiving intracranial pressure monitoring and neurointensive care at a…
Immune checkpoints inhibitors in the treatment of progressive multifocal leukoencephalopathy: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed immune checkpoint inhibitors (ICIs) for progressive multifocal leukoencephalopathy (PML), pooling reports involving 186 patients from 52 articles.
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