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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

AllClinical ResearchCase Reports
FeaturedCase ReportRheumatology

Rheumatoid factor positivity in ANCA-negative eosinophilic granulomatosis with polyangiitis: cardiac mimicry, mononeuritis multiplex, and long-term outcome in a case-based systematic review.

Rheumatol IntNov 10, 2026Open access

A 42-year-old woman with long-standing asthma and rheumatoid factor (RF) of 322 IU/mL presented with myocardial infarction-like cardiac involvement despite non-obstructive coronary arteries.

Clinical pearl

High RF positivity does not exclude EGPA. In a patient with asthma, eosinophilia, and compatible ENT, neurologic, or cardiac manifestations, consider EGPA even when ANCA is negative and RF is elevated.

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Also worth knowing

Case ReportOncology (Medical)Open access

Pediatric suprasellar primary CNS lymphoma with cavernous sinus invasion and ischemic stroke: a case report and systematic review.

A 12-year-old immunocompetent girl presented with high fever, severe headache, and diplopia, followed by rapid neurological deterioration.

Childs Nerv SystNov 3, 2026Read case
Case ReportInfectious DiseasesOpen access

Measles-like hypermutation of a Newcastle disease virus drives fatal encephalitis during BCMA × CD3 T-cell-redirecting immunotherapy.

A patient with multiple myeloma receiving maintenance teclistamab, daratumumab, and lenalidomide developed rapidly progressive brainstem-cerebellar encephalitis.

Acta NeuropatholNov 11, 2026Read case
Case ReportOncology (Medical)

Impact of nasogastric administration using the simple suspension method on serum tirabrutinib levels: A case report.

An 82-year-old man with relapsed primary central nervous system lymphoma began tirabrutinib at 320 mg/day while fasting. As dysphagia progressed, administration changed from swallowing tablets to nasogastric delivery by…

Am J Health Syst PharmNov 10, 2026Read case
Case ReportInfectious DiseasesOpen access

Multidisciplinary management of disseminated tuberculosis with tuberculous meningitis and active hepatitis B in a critically ill pregnant woman in the third trimester: a case report.

A 24-year-old woman at 30 weeks’ gestation presented with headache, vomiting, fever, and nuchal rigidity. Cerebrospinal fluid findings confirmed tuberculous meningitis, and chest CT showed diffuse miliary nodules…

Infect Dis PovertyNov 10, 2026Read case
Case ReportOncology (Medical)

Progression-Associated Loss of SMARCB1/INI1 Expression in Mismatch Repair-Deficient Glioblastoma.

A patient with mismatch repair-deficient glioblastoma had a recurrent tumor in which testing identified a second SMARCB1 mutation and complete loss of SMARCB1/INI1 protein expression.

Neuropathol Appl NeurobiolNov 7, 2026Read case
Case ReportNeurology

Clinical Reasoning: A 55-Year-Old Woman With a Hyperkinetic Movement Disorder, External Ophthalmoplegia, and Myopathy.

A 55-year-old woman was evaluated for an 8-year history of hyperkinetic movements. Her examination and clinical picture also included mild ataxia, spasticity in the lower limbs, external ophthalmoplegia, and myopathy.

NeurologyNov 11, 2026Read case
Case ReportPediatricsOpen access

Spontaneous recanalization of pediatric internal carotid artery dissection during aspirin monotherapy: a retrospective case series.

This retrospective series described five children with acute arterial ischemic stroke due to intracranial internal carotid artery dissection.

Childs Nerv SystNov 6, 2026Read case
Case ReportNeurologyOpen access

Identification of AKAP6 as a candidate gene for charcot-marie-tooth disease: expanding the clinical and molecular spectrum.

A family was evaluated for axonal sensorimotor polyneuropathy. Whole-exome sequencing, with copy-number variant detection and runs-of-homozygosity analysis, identified a homozygous nonsense variant in AKAP6, c.4774 C >…

Mol Biol RepNov 6, 2026Read case
Case ReportNeurologyOpen access

Clinical and genetic characterization of three Iranian patients carrying the CLCN1 p.Pro452Leu variant.

Three Iranian families were evaluated for clinical and electrical myotonia, characterized by delayed skeletal muscle relaxation after contraction.

Mol Biol RepNov 6, 2026Read case
Case ReportNeurology

Magnetic resonance neurography-supported L3-L4 radiculitis presenting as refractory peripatellar neuropathic pain in a patient with diabetes: A case report.

A 75-year-old man with longstanding type 2 diabetes developed severe burning, stabbing pain around the left kneecap, with numbness and touch-evoked allodynia but no back pain, typical radicular symptoms, weakness, or…

Medicine (Baltimore)Nov 6, 2026Read case
Case ReportNeurology

An encephalitis-like syndrome in an adult with methylmalonic acidemia and hyperhomocysteinemia: A case report.

A 56-year-old man developed fever and slowed responses, followed by disorganized speech, visual hallucinations, impaired consciousness, and pyramidal signs.

Medicine (Baltimore)Nov 6, 2026Read case

Showing 12 of 55 publications that cleared our clinical screen in the last 14 days.

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