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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

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FeaturedClinical ResearchMedical Genetics

Association of HTR3A and COMT polymorphisms with electroacupuncture response for chemotherapy-induced nausea and vomiting in breast cancer: a secondary analysis of a randomized controlled trial.

Support Care CancerNov 9, 2026Open access

This exploratory, treatment-stratified secondary analysis of a randomized controlled trial examined whether three HTR3A and COMT polymorphisms were associated with complete protection (CP) against chemotherapy-induced…

Why it matters

Variation in response to electroacupuncture may have a genetic component, and these findings identify candidate polymorphisms for further study of complete protection from chemotherapy-induced nausea and vomiting.

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Also worth knowing

Clinical ResearchCardiology

The relationship between sirtuin1 gene polymorphism and coronary heart disease: Systematic review and meta-analysis.

This systematic review and meta-analysis examined associations between four SIRT1 gene polymorphisms and coronary heart disease (CHD), drawing on 9 articles with 1,839 cases and 1,937 controls.

Medicine (Baltimore)Nov 6, 2026Read summary

Clinical ResearchPathology (Anatomic & Clinical)Open access

Molecular Diagnostics and Clinicopathologic Spectrum of Kinase Fusion-Positive Spindle Cell Neoplasms of the Oral and Maxillofacial Region: A Systematic Review and Pooled Patient-Level Analysis.

This systematic review and pooled patient-level analysis characterized kinase fusion-positive spindle cell neoplasms of the oral and maxillofacial region using published reports.

Head Neck PatholNov 9, 2026Read summary

Clinical ResearchRheumatology

Prevalence of generalized joint hypermobility, hypermobility spectrum disorders and Ehlers-Danlos syndrome: systematic review and meta-analysis.

This systematic review and meta-analysis assessed the prevalence of generalized joint hypermobility (GJH), hypermobility spectrum disorder (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS).

Rheumatol IntNov 5, 2026Read summary

Clinical ResearchNeurology

The shared genetic architecture of the TDP-43 spectrum: Bridging clinical FTLD and neuropathological endophenotypes.

This inverse-variance fixed-effects and random-effects meta-analysis examined shared genetic associations across neuropathological TDP-43 conditions and clinically diagnosed frontotemporal lobar degeneration (FTLD).

Alzheimers DementNov 1, 2026Read summary

Clinical ResearchPediatrics

A phase 2 study of tipifarnib in children and young adults with tumors harboring HRAS genomic alterations: NCI-COG Pediatric MATCH trial (APEC1621M).

This phase 2 NCI-COG Pediatric MATCH study evaluated intermittent oral tipifarnib in children and young adults with relapsed or refractory solid tumors carrying specified HRAS mutations.

OncologistNov 5, 2026Read summary

Clinical ResearchGastroenterologyOpen access

MLH1 AND MSH2 PROTEIN EXPRESSION LOSS AND MICROSATELLITE INSTABILITY IN COLORECTAL ADENOMAS OF PATIENTS WITH LYNCH SYNDROME: A SYSTEMATIC REVIEW AND META-ANALYSIS.

This systematic review and meta-analysis assessed the relationship between microsatellite instability (MSI) and loss of MLH1 or MSH2 expression in colorectal adenomas from people with Lynch syndrome.

Arq GastroenterolOct 30, 2026Read summary

Clinical ResearchNeurology

Germline Genetic Variants and Epilepsy Surgery Response: Individual Participant Pooled Analysis of 272 Patients.

This systematic review and individual-participant pooled analysis examined seizure outcomes after resection or laser ablation in 272 people with pathogenic or likely pathogenic germline epilepsy variants, excluding…

NeurologyNov 2, 2026Read summary

Clinical ResearchHematology

Genotypic-Phenotypic Correlations in Non-HbE β-Thalassemia Intermedia: A Geographic Systematic Review.

This PRISMA-guided systematic review qualitatively synthesized 21 studies of genotype–phenotype correlations in non-HbE β-thalassemia intermedia, a heterogeneous disorder now included within non-transfusion-dependent…

Mol Genet Genomic MedNov 1, 2026Read summary

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