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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

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FeaturedClinical ResearchHematology

Azacitidine-Venetoclax or Induction Chemotherapy for Acute Myeloid Leukemia.

N Engl J MedSep 3, 2026

This phase 2 randomized trial compared azacitidine plus venetoclax to induction chemotherapy in 172 previously untreated adults with acute myeloid leukemia (AML) eligible for induction.

Why it matters

The findings suggest that azacitidine-venetoclax may offer a more effective treatment option with a better safety profile for induction-eligible patients with AML, potentially changing standard treatment approaches.

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Also worth knowing

Clinical ResearchHematology

Concizumab in patients with hemophilia A or B without inhibitors: 56-week cutoff results of the phase 3 explorer8 study.

The phase 3 explorer8 study evaluated concizumab, a nonfactor replacement therapy, in males aged ≥12 years with hemophilia A or B without inhibitors.

Blood AdvSep 6, 2026Read summary
Clinical ResearchHematology

Comparative Efficacy of BTK Inhibitors in Treatment-Naïve and Relapsed/Refractory Mantle Cell Lymphoma: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis evaluated the efficacy of Bruton tyrosine kinase inhibitors (BTKis) in treatment-naïve and relapsed/refractory mantle cell lymphoma (MCL).

J Cell Mol MedSep 1, 2026Open accessRead summary
Clinical ResearchHematology

Outcomes of patients with myelofibrosis treated with ruxolitinib and anemia-supporting medications.

This post hoc analysis of the phase 3b JUMP trial examined the effects of adding anemia-supporting medications to ruxolitinib in 101 patients with myelofibrosis and anemia.

HematologySep 4, 2026Read summary
Clinical ResearchHematology

Frontline therapies for adult patients with newly diagnosed Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia: a systematic literature review.

This systematic review evaluated 96 studies on frontline therapies for adults with Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia (B-ALL).

HematologySep 8, 2026Read summary
Clinical ResearchHematology

Baricitinib for refractory chronic graft-versus-host disease: results of a phase 1/2 study.

This phase 1/2 study evaluated the safety and efficacy of baricitinib, a JAK 1/2 inhibitor, in 24 adults with refractory chronic graft-versus-host disease (cGVHD) after hematopoietic cell transplantation.

Blood AdvSep 6, 2026Open accessRead summary
Clinical ResearchCardiology

Prothrombin complex concentrate (PCC) vs. non-PCC strategies for warfarin reversal in left ventricular assist device recipients: A systematic review and meta-analysis.

This systematic review and meta-analysis evaluated prothrombin complex concentrate (PCC) versus non-PCC strategies for warfarin reversal in left ventricular assist device (LVAD) recipients.

Intensive Crit Care NursAug 29, 2026Read summary
Clinical ResearchInfectious Diseases

Convalescent Plasma Restores Viral Clearance After Anti-Spike Monoclonal Antibody Failure in Immunocompromised COVID-19 Patients: A Systematic Review and Meta-Analysis of Individual Patient Data.

This systematic review and meta-analysis evaluated the effectiveness of convalescent plasma (CCP) in immunocompromised COVID-19 patients who remained positive for SARS-CoV-2 after anti-Spike monoclonal antibody (mAb)…

Rev Med VirolSep 1, 2026Open accessRead summary
Clinical ResearchHematology

A Phase 1 Trial of Duvelisib and Oral Azacitidine in Relapsed/Refractory T-Cell Lymphoma.

This Phase I trial evaluated the combination of duvelisib and oral azacitidine in 14 patients with relapsed/refractory T-cell lymphoma.

Hematol OncolSep 1, 2026Open accessRead summary
Clinical ResearchHematology

Systematic review of machine learning approaches for predicting sickle cell crisis and mortality risk at the climate-health nexus.

This systematic review analyzed 34 studies on machine learning models predicting sickle cell anemia (SCA) crises and mortality, focusing on climate-related factors.

BMC Med Inform Decis MakSep 3, 2026Open accessRead summary
Clinical ResearchHematology

Cardiovascular disease and amyloidosis in phase III multiple myeloma trials: a systematic review of eligibility, screening and event reporting.

This systematic review evaluated phase III randomized controlled trials of multiple myeloma therapies, focusing on eligibility criteria related to cardiovascular disease (CVD) and amyloidosis.

Open HeartSep 1, 2026Open accessRead summary
Clinical ResearchHematology

Pain Management in Erythromelalgia: A Systematic Review and Graded Appraisal Across Etiological Subtypes.

This systematic review evaluated pain management strategies for erythromelalgia across various etiological subtypes, analyzing 25 studies involving 591 individuals.

Eur J PainSep 1, 2026Open accessRead summary

Showing 12 of 15 publications that cleared our clinical screen in the last 14 days.

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