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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

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FeaturedClinical ResearchGeneral Surgery

Impact of PerioperAtive LidocAine Infusions on Enhanced Recovery After Noncardiac Surgery (IMPALA-ERAS) in an inpatient setting: rationale, design and protocol for a sequential, repeated crossover trial.

BMJ OpenSep 8, 2026

The IMPALA-ERAS trial is a single-centre, pragmatic, cluster-randomised, double-blinded, placebo-controlled study evaluating the effects of perioperative intravenous lidocaine infusions on postoperative recovery in 2290…

Why it matters

Understanding the role of intravenous lidocaine in ERAS pathways could enhance postoperative recovery and reduce opioid consumption, addressing the ongoing challenge of opioid-related complications in surgical patients.

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Also worth knowing

Clinical ResearchAnesthesiology

Intravenous lidocaine reduces the propofol EC50 for loss of consciousness and intraoperative anesthetic consumption in gynecological laparoscopy: A randomized controlled trial .

This randomized controlled trial evaluated the effects of intravenous lidocaine on propofol requirements in 60 patients undergoing gynecological laparoscopy.

Pak J Pharm SciSep 9, 2026Read summary
Clinical ResearchObstetrics & Gynecology

Comparison of a Modified Regimen of Prophylactic Phenylephrine Boluses Versus Variable Rate Infusion During Elective Cesarean Delivery Under Spinal Anesthesia: A Noninferiority Randomized Double-Blind Study.

This randomized controlled trial compared a modified regimen of prophylactic phenylephrine boluses to a variable rate infusion during elective cesarean deliveries under spinal anesthesia in healthy pregnant women.

A A PractSep 8, 2026Read summary
Clinical ResearchGeneral Surgery

Efficacy and safety of laparoscopic-guided transversus abdominis plane block versus port-site local anesthetic infiltration in laparoscopic cholecystectomy: A systematic review, meta-analysis, and trial sequential analysis.

This systematic review and meta-analysis evaluated the efficacy and safety of laparoscopic-guided transversus abdominis plane (LTAP) block versus port-site local anesthetic infiltration in 711 patients undergoing…

Medicine (Baltimore)Sep 4, 2026Read summary
Clinical ResearchAnesthesiology

The effect of intravenous dexamethasone in supraclavicular brachial plexus block at Halibet National Referral Hospital, Eritrea 2024-2025: A randomized clinical trial.

This randomized clinical trial evaluated the effect of intravenous dexamethasone on postoperative analgesia in 60 patients undergoing upper limb surgery with supraclavicular brachial plexus block.

PLoS OneSep 3, 2026Open accessRead summary
Clinical ResearchAnesthesiology

Efficacy of different doses of oliceridine for Patient-Controlled Intravenous Analgesia in patients undergoing Total Laparoscopic Hysterectomy.

This randomized controlled trial evaluated the efficacy and safety of three doses of oliceridine (0.1, 0.35, and 0.5 mg/kg) for patient-controlled intravenous analgesia in patients undergoing total laparoscopic…

PLoS OneSep 3, 2026Open accessRead summary
Clinical ResearchAnesthesiology

Duloxetine for postoperative pain management in total hip and knee arthroplasty: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the efficacy of perioperative duloxetine for pain management in patients undergoing total hip and knee arthroplasties.

J Orthop Surg ResSep 2, 2026Open accessRead summary
Clinical ResearchAnesthesiology

Analgesic Effects of Intravenous Lidocaine in Laparoscopic Surgery: A Systematic Review and Meta-Analysis With Trial Sequential Analysis.

This systematic review and meta-analysis evaluated the effects of intravenous lidocaine on postoperative pain in adults undergoing laparoscopic surgery, including 45 randomized clinical trials with 2599 patients.

Clin J PainSep 1, 2026Read summary
Clinical ResearchAnesthesiology

Etomidate combined with TAPB in ovarian cancer surgery: A controlled study on hemodynamics and immune response.

This randomized controlled trial evaluated the effects of etomidate combined with transversus abdominis plane block (TAPB) on hemodynamics and immune response in 80 patients undergoing ovarian cancer surgery.

Pak J Pharm SciSep 1, 2026Read summary
Clinical ResearchAnesthesiology

Rebound Pain and Patient Satisfaction With Dexamethasone as an Adjunct for Peripheral Nerve Blocks. A Substudy Based on Two Randomised Clinical Trials.

This substudy pooled data from two randomized controlled trials to evaluate the effect of dexamethasone on pain and rebound pain after peripheral nerve blocks in 159 patients undergoing osseous surgery.

Acta Anaesthesiol ScandSep 1, 2026Open accessRead summary
Clinical ResearchAnesthesiology

The effect of BIS-guided sevoflurane anesthesia on postoperative nausea and vomiting in pediatric adenoidectomy: a prospective randomized controlled trial.

This prospective randomized controlled trial evaluated the impact of BIS-guided sevoflurane anesthesia on postoperative nausea and vomiting (PONV) in 58 children aged 3-8 undergoing adenoidectomy.

Sao Paulo Med JAug 31, 2026Open accessRead summary
Clinical ResearchAnesthesiology

A Novel Multiple Sensory Nerve Block Combination Using Ultrasound Guidance in Knee Arthroplasty: A Randomized Clinical Trial.

This randomized clinical trial evaluated the efficacy of an eight-nerve block combination for pain relief after total knee arthroplasty (TKA) compared to local infiltration analgesia (LIA).

A A PractSep 8, 2026Read summary

Showing 12 of 19 publications that cleared our clinical screen in the last 14 days.

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