Trending archive
Every article that has appeared in Trending stays here. Search by title, journal, author or PMID, and narrow by date.
52 articles
November 20264
A case report of ultra-rare SMARCD2 deficiency and review of the literature.
The report describes a patient with congenital neutropenia due to specific granule deficiency type 2, a syndromic autosomal recessive disorder associated with loss-of-function variants in SMARCD2.
Sirolimus-induced improvement of immune dysregulation associated hepatosplenomegaly in common variable immunodeficiency: a case-based review.
A 50-year-old woman with common variable immunodeficiency (CVID), treated with regular intravenous immunoglobulin replacement, developed progressive hepatosplenomegaly, cytopenias, abdominal enlargement, dyspnea…
"Fatal venous thromboembolism and divergent phenotypes in DOCK8 deficiency: a three-sibling case series".
Three siblings with genetically confirmed DOCK8 deficiency had early-onset atopic dermatitis, recurrent respiratory infections, and failure to thrive. All developed bronchiectasis and severe viral infections.
Peanut Allergy and the Basophil Activation Test in the Military Healthcare System: A Case Series of Monozygotic Twins.
Two adolescent monozygotic twins in a military family had longstanding peanut-allergy labels based on positive routine allergy tests.
October 202612
Treatment-refractory chronic urticaria with neutrophilia and elevated inflammatory markers.
A 38-year-old man had long-standing chronic urticaria that persisted despite standard guideline-directed treatment. Persistent neutrophilia and elevated inflammatory markers raised concern that the presentation might…
Disruption of the N-terminal domain in a STAT3 hyper-IgE syndrome variant causes disease by sequestering STAT3 in the cytoplasm.
A patient with a STAT3 R31Q variant presented with disseminated invasive aspergillosis involving the brain and lung, bronchiectasis, and elevated serum IgE, without nonimmune manifestations of hyper-IgE syndrome.
Delayed serum sickness-like reaction mimicking septic shock after antivenom therapy: A case report.
A woman in her early 60s returned about 7 days after antivenom therapy with widespread urticarial and purpuric maculopapular rash, itching, fever, vomiting, fatigue, dizziness, hypotension, and thrombocytopenia.
Approach to the patient with APS-1/APECED.
This article presents five cases of autoimmune polyendocrine syndrome type 1 (APS-1/APECED), a disorder caused by impaired immune tolerance and typically associated with biallelic AIRE variants.
Bee Sting-Associated Kounis Syndrome Presenting as Myocardial Infarction: A Case Report and Systematic Review with Age-Based Analysis.
A 44-year-old man presented with myocardial infarction after a probable bee sting-associated allergic reaction and was considered to have Kounis syndrome, an acute coronary syndrome linked to hypersensitivity.
Long-Term Follow-Up of Epidermolysis Bullosa Acquisita with Fluctuations in Serum Cytokine Levels: A Case Report.
A 47-year-old man with epidermolysis bullosa acquisita (EBA) had a disease course lasting more than 10 years. Serial testing showed that anti-basement membrane zone IgG and anti-type VII collagen antibody titers…
Food-Associated Kounis Syndrome: Clinical Spectrum and Diagnostic Considerations from a Case Report and Systematic Qualitative Synthesis of Published Cases.
The supplied abstract does not describe an individual patient’s presentation, diagnostic findings, or outcome. It reports a qualitative synthesis of published food-associated Kounis syndrome cases: 53 patients across 50…
Allergic bronchopulmonary mycosis associated with Talaromyces boninensis: A case report.
A patient was evaluated for allergic bronchopulmonary mycosis (ABPM), an airway hypersensitivity disorder that can be caused by fungi other than Aspergillus.
CHAPLE-Like Enteropathy and Renal Microangiopathy in an Adult Patient With CD46 Deficiency.
A 23-year-old woman with childhood-onset enteropathy and hypogammaglobulinemia had been treated with immunoglobulin replacement for presumed common variable immunodeficiency.
Adult-Onset Henoch-Schönlein Purpura Triggered by Isotretinoin with Persistent Polyarthritis and Isolated Cutaneous-Gastrointestinal Involvement: A Case Report.
A 30-year-old woman developed palpable purpura, abdominal pain, and symmetric polyarthritis three weeks after starting isotretinoin.
Anaphylaxis Following Intravenous Methylprednisolone Sodium Succinate: A Case Report.
A 45-year-old woman with rheumatoid arthritis developed generalized pruritic erythema and raised lesions, dyspnea, hypoxemia, bradycardia, and reduced consciousness within 5 minutes of starting intravenous…
Suspected allergic bronchopulmonary candidiasis in a patient with concurrent multidrug-resistant bacterial pneumonia: A case report.
A 70-year-old man with a history of hypertension and cerebral infarction presented with sudden right limb weakness and was diagnosed with hemorrhagic cerebral infarction.
September 20268
Mild Phenotype in Functionally Validated STAT1 Gain-of-Function Disease Due to a Novel DNA-Binding Variant.
A case report describes four patients with STAT1 gain-of-function disease, focusing on three related individuals with a novel p.Leu400Pro variant.
Anaphylaxis to both pegfilgrastim and sargramostim in a patient with diffuse large B-cell lymphoma.
A woman in her early 60s with stage 3A diffuse large B-cell lymphoma experienced anaphylaxis to pegfilgrastim after her first cycle of R-CHOP chemotherapy, presenting with syncope and severe hypotension.
Acute Hepatocellular Drug-induced Liver Injury following Cosmetic Liquid Lipo Injection Complicated by Anaphylactic Reaction to N-acetylcysteine.
A 31-year-old woman without prior liver disease developed nausea, vomiting, jaundice, and generalized pruritus shortly after a cosmetic “liquid lipo” injection containing deoxycholic acid, phosphatidylcholine, and…
Complicated allergic fungal rhinosinusitis: diagnostic complexities and management strategies.
A man in his 60s presented with diplopia, headache, and facial numbness, leading to a diagnosis of bilateral abducens nerve palsy and partial right third nerve palsy.
Novel TRAC variant causing autosomal recessive TCR-alpha/beta deficient immunodeficiency 7.
Monozygotic twin brothers presented in early infancy with severe, recurrent diarrhoea and profound T-cell lymphopenia. Immunological assessment revealed significantly reduced immunoglobulins and very low CD3+, CD4+, and…
Déjà vu.
A male in his mid-20s presented with fever, purpuric rash, neuropathy, marked eosinophilia, hepatic dysfunction, and extensive multisystem thrombosis.
A Novel De Novo STAG1 Variant at the RAD21 Binding Interface Is Associated With Hypoglycemia, Recurrent Fever, Immunodeficiency and Features of Classical Cohesinopathies.
A 5-year-old boy had developmental delay and intellectual disability with feeding difficulties, alongside hypoglycemia, recurrent fever, and immunodeficiency.
Levocetirizine-induced paradoxical fixed drug eruption: A case report with causality assessment.
A patient developed a fixed drug eruption (FDE) after self-medicating with levocetirizine, presenting with hyperpigmented patches that progressed to blisters.
Stay updated for free
Get the 3 most interesting publications in one specialty each week.
Weekly email. Unsubscribe anytime.
Want this personalized?
Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.
- Your specialties
- Your filters and thresholds
- Clinical Research + Case Reports, tuned separately
- Automatic weekly delivery
- Audio and text
Prefer listening? Personalized audio digests are available with Pro.