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495 articles
September 202624
Previously unreported pathogenic variant in FOXC1 causing Axenfeld-Rieger syndrome with significant ocular anterior segment dysgenesis.
A patient presented with Axenfeld-Rieger syndrome, exhibiting significant ocular anterior segment dysgenesis. Genetic testing revealed heterozygosity for a previously unreported pathogenic variant in the FOXC1 gene.
Ophthalmic artery occlusion following local hyaluronic acid injection: A case report.
A 46-year-old female experienced sudden vision loss and skin mottling after hyaluronic acid injection into the nasal bridge.
Lipidomic profiles and their relationship to incident diabetic retinopathy in type 2 diabetes: The Fremantle Diabetes Study Phase II.
This exploratory longitudinal study examined whether baseline plasma lipid profiles predicted diabetic retinopathy (DR) in 762 adults with type 2 diabetes.
Adjunctive Orbital Radiation Therapy with Teprotumumab in Recalcitrant Thyroid Eye Disease: A Case Report.
A patient with recalcitrant, muscle-predominant thyroid eye disease had radiographic apical crowding and repeated reactivations despite multiple courses of teprotumumab and immunomodulatory therapies.
USP6-FISH Negative Nodular Fasciitis: Benign Impostor of the Orbit.
An 11-year-old boy had a painless, progressively enlarging periorbital mass initially thought to be a dermoid cyst. Ultrasound was reassuring, but MRI showed an enhancing lesion concerning for neoplasm, leading to…
Endogenous endophthalmitis caused by Klebsiella pneumoniae secondary to prostatic abscess: a report of two cases.
Two men developed endogenous endophthalmitis associated with Klebsiella pneumoniae prostatic abscesses. A 37-year-old presented with fever and lower urinary tract symptoms followed by acute visual loss; blood and urine…
Clinical Reasoning: A 60-Year-Old Diabetic Woman With Fluctuating Visual Disturbances.
A 60-year-old woman with poorly controlled diabetes presented with fluctuating visual disturbances, including bilateral homonymous visual field defects and positive visual phenomena.
Renal Safety of Intravitreal Ranibizumab and the Effects of SGLT2 Inhibition in Diabetic Macular Oedema: A Post Hoc Analysis of the COMET Trial.
This post hoc analysis of the prospective COMET randomised controlled trial examined whether intravitreal ranibizumab (IVR) exposure was associated with renal markers in 53 participants with diabetic macular oedema, and…
Vogt-Koyanagi-Harada Disease Presenting With Progressive Visual Loss and Multisystem Involvement: A Case Report.
A 55-year-old Indian man presented with a 20-day history of progressive bilateral visual loss, headache, and hearing impairment.
Relationship of Neighborhood Socioeconomic Deprivation With Glaucoma Severity and Medication Adherence in Veterans.
This secondary analysis of a randomized controlled trial examined whether neighborhood socioeconomic deprivation, measured by Area Deprivation Index (ADI), was associated with glaucoma severity or medication adherence…
Traumatic canalicular laceration and complex eyelid injury in a newborn delivered by forceps.
A newborn sustained complex upper eyelid lacerations and canalicular injury due to forceps-assisted delivery after obstructed labor.
Effect of a modified soft contact lens combined with a noncontact wide-angle viewing system during vitrectomy.
This randomized controlled trial evaluated the effectiveness of a modified soft contact lens (MSCL) in maintaining visual clarity and protecting the cornea during vitrectomy.
Severe vaso-occlusive lupus retinopathy: Purtscher-like retinopathy: a case report.
A 24-year-old female with systemic lupus erythematosus (SLE) developed blurred vision following COVID-19 infection, later presenting with fever, lymphadenopathy, seizures, and altered consciousness.
Costs of surgeries in low- and middle-income countries: a systematic literature review.
This systematic review analyzed 74 studies on surgical costs in low- and middle-income countries (LMICs) from January 2000 to June 2023.
Biomarkers for detecting and predicting macular neovascularization in age-related macular degeneration using optical coherence tomography angiography: a systematic review.
This systematic review assessed the effectiveness of optical coherence tomography angiography (OCTA)-derived biomarkers in detecting and predicting macular neovascularization (MNV) in age-related macular degeneration…
Effect of fenofibrate on diabetic retinopathy progression: an RCT-Only systematic review and meta-analysis incorporating the LENS trial.
This pre-registered systematic review and meta-analysis included randomized trials of fenofibrate reporting eye outcomes in adults with diabetes, predominantly type 2.
Nd: YAG laser rescue of sulcus-placed glaucoma drainage device tube occlusion: a two-case series.
Two cases of postoperative tube obstruction in patients with Aurolab Aqueous Drainage Implants (AADI) were treated with Nd: YAG laser.
Autologous bone grafts versus alloplastic implants for orbital floor reconstruction: a systematic review and meta-analysis.
This systematic review and meta-analysis compared autologous bone grafts and alloplastic implants for orbital floor reconstruction in 2,119 patients.
Endoscopic Endonasal Resection of a Pure Optic Canal Cavernous Malformation Presenting as Progressive Optic Neuropathy.
A 48-year-old woman presented with a 3-month history of progressive right visual decline, characterized by decreased visual acuity and visual field narrowing. MRI revealed a well-defined mass in the right optic canal.
Visual dysfunction and psychosis: A systematic review and meta-analysis.
This systematic review and meta-analysis examined links between visual dysfunction and psychosis-related outcomes across 56 studies, including longitudinal, genetically informed, case-control, cross-sectional, and…
Evaluation of a cornea-specialized large language model for diagnostic and management accuracy in complex corneal cases.
This randomized controlled trial assessed the effectiveness of a cornea-specialized large language model (LLM) in improving diagnostic and management accuracy in complex corneal cases among three cornea trainees.
Orbital spindle cell neoplasm with neural differentiation: diagnostic challenges in the absence of molecular confirmation.
An 82-year-old man with previously treated rectal adenocarcinoma developed progressive orbital pain and right-sided proptosis. CT showed an orbital-apex soft-tissue mass without bone erosion.
Early Diagnosis of Upper Eyelid Pyoderma Gangrenosum Using the PARACELSUS Score and Tissue-Sparing Management With Adjunctive Hypochlorous Acid Therapy: A Case Report.
A 17-year-old patient with ulcerative colitis developed progressive upper-eyelid ulceration, initially managed as preseptal cellulitis and later considered a possible necrotizing infection.
LYNX-1: A Phase 3 Study of 0.75% Phentolamine Ophthalmic Solution in Subjects With Dim Light Vision Disturbances.
LYNX-1 was a phase 3, multicenter, double-masked, randomized, placebo-controlled trial of nightly 0.75% phentolamine ophthalmic solution (POS) in about 145 people with dim light vision disturbances, enlarged mesopic…
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